ReviewEnvironmental health perspectives2001
Cross-species and interassay comparisons of phytoestrogen action.
Review in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed.
- The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- Effect of Diets Containing Phytoestrogen on Livestock Production: Nutrient Utilization, Carcass Traits, Lactational Performance, and Reproductive Function-A Review.Molecules (Basel, Switzerland) · 2026Review
- Evaluating the Antioxidant Potential of Coumestrol in the Treatment of Tripterygium Glycoside-Induced Oligospermia in Rats and Its Potential Mechanisms.Veterinary sciences · 2026Article
- Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessment.Environment international · 2025Article
- Roles of genistein in learning and memory during aging and neurological disorders.Biogerontology · 2023Review
- Developmental exposure to phytoestrogens found in soy: New findings and clinical implications.Biochemical pharmacology · 2022Review
- Comparing the effect of tempe flour and tofu flour consumption on estrogen serum in ovariectomized rats.Heliyon · 2019Article
- Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Clinical and experimental reproductive medicine · 2018Article
- Short-Term Soy Protein Isolate Feeding Prevents Liver Steatosis and Reduces Serum ALT and AST Levels in Obese Female Zucker Rats.Biomedicines · 2018Article
- Review
- Metabolism Disrupting Chemicals and Alteration of Neuroendocrine Circuits Controlling Food Intake and Energy Metabolism.Frontiers in endocrinology · 2018Review
- Dietary soy isoflavones during pregnancy suppressed the immune function in male offspring albino rats.Toxicology reports · 2018Article
- Phytoestrogen Concentrations in Human Urine as Biomarkers for Dietary Phytoestrogen Intake in Mexican Women.Nutrients · 2017Article
- Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects?International journal of molecular sciences · 2017Review
- Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours.The Proceedings of the Nutrition Society · 2017Review
- Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro.Toxicology and applied pharmacology · 2016Article
- Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Central inflammatory response to experimental stroke is inhibited by a neuroprotective dose of dietary soy.Brain research · 2014Article
- Isoflavones: estrogenic activity, biological effect and bioavailability.European journal of drug metabolism and pharmacokinetics · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper compiles animal and human data on the biologic effects and exposure levels of phytoestrogens in order to identify areas of research in which direct species comparisons can be made. In vitro and in vivo assays of phytoestrogen action and potency are reviewed and compared to actions, dose-response relationships, and estimates of exposure in human subjects. Binding studies show that the isoflavonoid phytoestrogens are high-affinity ligands for estrogen receptors (ERs), especially ER beta, but have lower potency in whole-cell assays, perhaps because of interactions with binding proteins. Many other enzymatic actions require concentrations higher than those normally seen in plasma. In vivo data show that phytoestrogens have a wide range of biologic effects at doses and plasma concentrations seen with normal human diets. Significant in vivoresponses have been observed in animal and human tests for bone, breast, ovary, pituitary, vasculature, prostate, and serum lipids. The doses reported to be biologically active in humans (0.4--10 mg/kg body weight/day) are lower than the doses generally reported to be active in rodents (10--100 mg/kg body weight/day), although some studies have reported rodent responses at lower doses. However, available estimates of bioavailability and peak plasma levels in rodents and humans are more similar. Steroidogenesis and the hypothalamic-pituitary-gonadal axis appear to be important loci of phytoestrogen actions, but these inferences must be tentative because good dose-response data are not available for many end points. The similarity of reported proliferative and antiproliferative doses illustrates the need for fuller examination of dose-response relationships and multiple end points in assessing phytoestrogen actions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.