Evidence map›Paper›PMID 11250736›Full record

ReviewBreast cancer research : BCR2000

Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants.

C G Kleer, K L van Golen, S D Merajver

Open access · goldAbstract readReview
In one paragraph

Review in Breast cancer research : BCR, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 211 citations in OpenAlex.

  1. Pooled it
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  4. A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2010
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

C G KleerDepartment of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0948, USA.
K L van Golen
S D Merajver
University of Michigan · US

Funding

PREVENTION OF MAMMARY CANCER IN HER-2NEU TRANSGENIC MICER01CA077612 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERAJVER, SOFIA DIANA · 1999 to 2007
$2.2M
NCI NIH HHS R01 CA077612NCI NIH HHS R01-CA77612
6 · The paper itself

Abstract

Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a clinically and pathologically distinct form of LABC that is particularly fast growing, invasive, and angiogenic. Nearly all women have lymph node involvement at the time of diagnosis, and approximately 36% have gross distant metastases. Despite recent advances in multimodality treatments, the prognosis of patients with IBC is poor, with a median disease-free survival of less than 2.5 years. Recent work on the genetic determinants that underlie the IBC phenotype has led to the identification of genes that are involved in the development and progression of this disease. This work has been aided by the establishment of primary human cell lines and animal models. These advances suggest novel targets for future interventions in the diagnosis and treatment of IBC.

Indexed as

AnimalsBreast NeoplasmsCarcinomaChemotherapy, AdjuvantClinical Trials as TopicCombined Modality TherapyCytokinesDisease-Free SurvivalEndothelial Growth FactorsEstrogensFemaleGenes, p53HumansInflammationLymphatic MetastasisLymphokinesCytokinesEndothelial Growth FactorsEstrogensLymphokinesNeoplasm ProteinsProgesteroneReceptors, EstrogenReceptors, ProgesteroneVascular Endothelial Growth Factor AVascular Endothelial Growth Factors

Identifiers

PMID11250736
PMCPMC138665
OpenAlexW2109781138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.