ReviewBreast cancer research : BCR2000
Transforming growth factor-beta and breast cancer: Mammary gland development.
Review in Breast cancer research : BCR, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 78 citations in OpenAlex.
- Milk levels of transforming growth factor beta 1 identify mothers with low milk supply.PloS one · 2024Article
- In silico pathway analysis based on chromosomal instability in breast cancer patients.BMC medical genomics · 2020Article
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- The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk.Cancer research · 2014Article
- Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts.Oncogene · 2014Article
- Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer.Endocrine reviews · 2013Review
- The biology of progesterone receptor in the normal mammary gland and in breast cancer.Molecular and cellular endocrinology · 2012Review
- Lysophosphatidic acid-induced p21Waf1 expression mediates the cytostatic response of breast and ovarian cancer cells to TGFβ.Molecular cancer research : MCR · 2011Article
- A functional polymorphism of TGFBR2 is associated with risk of breast cancer with ER(+), PR(+), ER(+)PR(+) and HER2(-) expression in women.Oncology letters · 2011Article
- Consequences of epithelial or stromal TGFβ1 depletion in the mammary gland.Journal of mammary gland biology and neoplasia · 2011Article
- The role of activin in mammary gland development and oncogenesis.Journal of mammary gland biology and neoplasia · 2011Review
- Mammary gland reprogramming: metalloproteinases couple form with function.Cold Spring Harbor perspectives in biology · 2011Review
- Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis.PloS one · 2011Article
- A human functional protein interaction network and its application to cancer data analysis.Genome biology · 2010Article
- Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence.Cancer science · 2009Article
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- ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells.Oncogene · 2007Article
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- The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.Breast cancer research : BCR · 2006Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor (TGF)-beta1 is a pluripotent cytokine that profoundly inhibits epithelial proliferation, induces apoptosis, and influences morphogenesis by mediating extracellular matrix deposition and remodeling. The physiologic roles of the action of TGF-beta in mammary gland, indeed in most tissues, are poorly understood. In order to understand the actions of TGF-beta, we need to take into account the complexity of its effects on different cell types and the influence of context on cellular responses. This task is further compounded by multiple mechanisms for regulating TGF-beta transcription, translation, and activity. One of the most significant factors that obscures the action of TGF-beta is that it is secreted as a stable latent complex, which consists of the 24-kDa cytokine and the 80-kDa dimer of its prepro region, called latency-associated peptide. Latency imposes a critical restraint on TGF-beta activity that is often overlooked. The extracellular process known as activation, in which TGF-beta is released from the latent complex, is emphasized in the present discussion of the role of TGF-beta in mammary gland development. Definition of the spatial and temporal patterns of latent TGF-beta activation in situ is essential for understanding the specific roles that TGF-beta plays during mammary gland development, proliferation, and morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.