ArticleCurrent biology : CB2001
eat-11 encodes GPB-2, a Gbeta(5) ortholog that interacts with G(o)alpha and G(q)alpha to regulate C. elegans behavior.
Article in Current biology : CB, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- G protein regulatory network shapes magnitude and kinetics of behavioral responses in an engineered opioid receptor model.The Journal of biological chemistry · 2026Article
- Histidine dephosphorylation of the Gβ protein GPB-1 promotes axon regeneration in C. elegans.EMBO reports · 2022Article
- Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction.Human molecular genetics · 2022Article
- The muscarinic agonist arecoline suppresses motor circuit hyperactivity inmicroPublication biology · 2020Article
- Review
- Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans.WormBook : the online review of C. elegans biology · 2018Review
- Genome-Wide Screen for Genes Involved inG3 (Bethesda, Md.) · 2017Article
- De novo analysis of the transcriptome of Pratylenchus zeae to identify transcripts for proteins required for structural integrity, sensation, locomotion and parasitism.Molecular plant pathology · 2016Article
- Pharyngeal pumping in Caenorhabditis elegans depends on tonic and phasic signaling from the nervous system.Scientific reports · 2016Article
- A Generative Statistical Algorithm for Automatic Detection of Complex Postures.PLoS computational biology · 2015Article
- Article
- Neuronal Goα and CAPS regulate behavioral and immune responses to bacterial pore-forming toxins.PloS one · 2013Article
- The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity.PLoS genetics · 2013Article
- Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.The Journal of biological chemistry · 2012Article
- GABAergic synaptic plasticity during a developmentally regulated sleep-like state in C. elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.The Journal of biological chemistry · 2010Article
- RSBP-1 is a membrane-targeting subunit required by the Galpha(q)-specific but not the Galpha(o)-specific R7 regulator of G protein signaling in Caenorhabditis elegans.Molecular biology of the cell · 2010Article
- A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans.PLoS biology · 2008Article
- Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Crystal structure of the multifunctional Gbeta5-RGS9 complex.Nature structural & molecular biology · 2008Article
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5 authors.
Funding
Abstract
In C. elegans, a G(o)/G(q) signaling network regulates locomotion and egg laying [1-8]. Genetic analysis shows that activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is suppressed by perturbations of this network, which include loss of the GOA-1 G(o)alpha, DGK-1 diacylglycerol kinase, EAT-16 G protein gamma subunit-like (GGL)-containing RGS protein, or an unidentified protein encoded by the gene eat-11 [9]. We cloned eat-11 and report that it encodes the Gbeta(5) ortholog GPB-2. Gbeta(5) binds specifically to GGL-containing RGS proteins, and the Gbeta(5)/RGS complex can promote the GTP-hydrolyzing activity of Galpha subunits [10, 11]. However, little is known about how this interaction affects G protein signaling in vivo. In addition to EAT-16, the GGL-containing RGS protein EGL-10 participates in G(o)/G(q) signaling; EGL-10 appears to act as an RGS for the GOA-1 G(o)alpha, while EAT-16 appears to act as an RGS for the EGL-30 G(q)alpha [4, 5]. We have combined behavioral, electrophysiological, and pharmacological approaches to show that GPB-2 is a central member of the G(o)/G(q) network and that GPB-2 may interact with both the EGL-10 and EAT-16 RGS proteins to mediate the opposing activities of G(o)alpha and G(q)alpha. These interactions provide a mechanism for the modulation of behavior by antagonistic G protein networks.
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