ArticleAmerican journal of physiology. Renal physiology2001
Influence of Ca(2+)-activated K(+) channels on rat renal arteriolar responses to depolarizing agonists.
Article in American journal of physiology. Renal physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- CaMolecules (Basel, Switzerland) · 2023Review
- Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole.American journal of physiology. Renal physiology · 2018Article
- Article
- Differential effects of superoxide and hydrogen peroxide on myogenic signaling, membrane potential, and contractions of mouse renal afferent arterioles.American journal of physiology. Renal physiology · 2016Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Interacting influence of diuretics and diet on BK channel-regulated K homeostasis.Current opinion in pharmacology · 2014Review
- Smooth muscle contractile diversity in the control of regional circulations.American journal of physiology. Heart and circulatory physiology · 2014Review
- Hydrogen sulphide-mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats.British journal of pharmacology · 2013Article
- Function and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cells.Drug discovery today · 2012Review
- Vascular BK channel deficiency exacerbates organ damage and mortality in endotoxemic mice.Journal of cardiovascular pharmacology · 2012Article
- Closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats.Pflugers Archiv : European journal of physiology · 2011Article
- Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.American journal of physiology. Heart and circulatory physiology · 2010Article
- Potassium channel contributions to afferent arteriolar tone in normal and diabetic rat kidney.American journal of physiology. Renal physiology · 2008Article
- Kv channel subunits that contribute to voltage-gated K+ current in renal vascular smooth muscle.Pflugers Archiv : European journal of physiology · 2003Article
- Altered electromechanical coupling in the renal microvasculature during the early stage of diabetes mellitus.Clinical and experimental pharmacology & physiologyReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Experiments were performed to evaluate the hypothesis that opening of Ca(2+)-activated K(+) channels (BK(Ca) channels) promotes juxtamedullary arteriolar dilation and curtails constrictor responses to depolarizing agonists. Under baseline conditions, afferent and efferent arteriolar lumen diameters averaged 23.4 +/- 0.9 (n = 36) and 22.8 +/- 1.1 (n = 13) microm, respectively. The synthetic BK(Ca) channel opener NS-1619 evoked concentration-dependent afferent arteriolar dilation. BK(Ca) channel blockade (1 mM tetraethylammonium; TEA) decreased afferent diameter by 15 +/- 3% and prevented the dilator response to 30 microM NS-1619. ANG II (10 nM) decreased afferent arteriolar diameter by 44 +/- 4%, a response that was reduced by 30% during NS-1619 treatment; however, TEA failed to alter afferent constrictor responses to either ANG II or arginine vasopressin. Neither NS-1619 nor TEA altered agonist-induced constriction of the efferent arteriole. Thus, although the BK(Ca) channel agonist was able to curtail afferent (but not efferent) arteriolar constrictor responses to ANG II, BK(Ca) channel blockade did not allow exaggerated agonist-induced arteriolar constriction. These observations suggest that the BK(Ca) channels evident in afferent arteriolar smooth muscle do not provide a prominent physiological brake on agonist-induced constriction under our experimental conditions.
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