ArticleProceedings of the National Academy of Sciences of the United States of America2001
Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Integrative Analyses of Circulating Small RNAs and Kidney Graft Transcriptome in Transplant Glomerulopathy.International journal of molecular sciences · 2021Trial
- Cardiac allograft vasculopathy: current review and future research directions.Cardiovascular research · 2021Review
- Tumor-infiltrating lymphocytes in the immunotherapy era.Cellular & molecular immunology · 2021Review
- Adoptive Transfer of Regulatory Immune Cells in Organ Transplantation.Frontiers in immunology · 2021Review
- Extracellular vesicles in allograft rejection and tolerance.Cellular immunology · 2020Review
- PIRCHE-II: an algorithm to predict indirectly recognizable HLA epitopes in solid organ transplantation.Immunogenetics · 2020Review
- Innate Functions of Dendritic Cell Subsets in Cardiac Allograft Tolerance.Frontiers in immunology · 2020Review
- State of the Art: Role of the Dendritic Cell in Induction of Allograft Tolerance.Transplantation · 2018Review
- Emerging role of exosomes in allorecognition and allograft rejection.Current opinion in organ transplantation · 2018Review
- T cell Allorecognition Pathways in Solid Organ Transplantation.Frontiers in immunology · 2018Review
- Alloimmune T cells in transplantation.The Journal of clinical investigation · 2017Review
- The exciting "bench to bedside" journey of cell therapies for acute kidney injury and renal transplantation.Journal of nephrology · 2017Review
- Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry.Journal of visualized experiments : JoVE · 2017Article
- Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation.Science immunology · 2016Article
- Quantification of CD4(+) T Cell Alloreactivity and Its Control by Regulatory T Cells Using Time-Lapse Microscopy and Immune Synapse Detection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Article
- Allorecognition by T Lymphocytes and Allograft Rejection.Frontiers in immunology · 2016Review
- Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Article
- Both rejection and tolerance of allografts can occur in the absence of secondary lymphoid tissues.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Cell therapy to induce allograft tolerance: time to switch to plan B?Frontiers in immunology · 2015Review
- Primary vascularization of allografts governs their immunogenicity and susceptibility to tolerogenesis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Graft loss from chronic rejection has become the major obstacle to the long-term success of whole organ transplantation. In cardiac allografts, chronic rejection is manifested as a diffuse and accelerated form of arteriosclerosis, termed cardiac allograft vasculopathy. It has been suggested that T-cell recognition of processed alloantigens (allopeptides) presented by recipient antigen-presenting cells through the indirect pathway of allorecognition plays a critical role in the development and progression of chronic rejection. However, definitive preclinical evidence to support this hypothesis is lacking. To examine the role of indirect allorecognition in a clinically relevant large animal model of cardiac allograft vasculopathy, we immunized MHC inbred miniature swine with synthetic polymorphic peptides spanning the alpha(1) domain of an allogeneic donor-derived swine leukocyte antigen class I gene. Pigs immunized with swine leukocyte antigen class I allopeptides showed in vitro proliferative responses and in vivo delayed-type hypersensitivity responses to the allogeneic peptides. Donor MHC class I disparate hearts transplanted into peptide-immunized cyclosporine-treated pigs not only rejected faster than unimmunized cyclosporine-treated controls (mean survival time = 5.5 +/-1.7 vs. 54.7 +/-3.8 days, P < 0.001), but they also developed obstructive fibroproliferative coronary artery lesions much earlier than unimmunized controls (<9 vs. >30 days). These results definitively link indirect allorecognition and cardiac allograft vasculopathy.
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