ArticleProceedings of the National Academy of Sciences of the United States of America2001
Genomic evidence for a complete sexual cycle in Candida albicans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 195 citations in OpenAlex.
- Parasex generates highly recombinant progeny in Candida albicans with increased virulence.Nature microbiology · 2026Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Spo11: from topoisomerase VI to meiotic recombination initiator.Biochemical Society transactions · 2025Review
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Divergence and conservation of the meiotic recombination machinery.Nature reviews. Genetics · 2024Review
- Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens,Current clinical microbiology reports · 2023Review
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Is Candida auris sexual?PLoS pathogens · 2020Review
- Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs.eLife · 2020Article
- Metabolism-induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells.The EMBO journal · 2019Article
- A 'parameiosis' drives depolyploidization and homologous recombination in Candida albicans.Nature communications · 2019Article
- Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution.Microbiology spectrum · 2017Review
- Genome management and mismanagement--cell-level opportunities and challenges of whole-genome duplication.Genes & development · 2015Review
- The parasexual lifestyle of Candida albicans.Current opinion in microbiology · 2015Review
- Sexual reproduction of human fungal pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity.Cold Spring Harbor perspectives in medicine · 2014Review
- Origins of eukaryotic sexual reproduction.Cold Spring Harbor perspectives in biology · 2014Review
- Unisexual reproduction.Advances in genetics · 2014Review
- Parasexuality and ploidy change in Candida tropicalis.Eukaryotic cell · 2013Article
- Species and condition specific adaptation of the transcriptional landscapes in Candida albicans and Candida dubliniensis.BMC genomics · 2013Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Candida albicans is a diploid fungus that has become a medically important opportunistic pathogen in immunocompromised individuals. We have sequenced the C. albicans genome to 10.4-fold coverage and performed a comparative genomic analysis between C. albicans and Saccharomyces cerevisiae with the objective of assessing whether Candida possesses a genetic repertoire that could support a complete sexual cycle. Analyzing over 500 genes important for sexual differentiation in S. cerevisiae, we find many homologues of genes that are implicated in the initiation of meiosis, chromosome recombination, and the formation of synaptonemal complexes. However, others are striking in their absence. C. albicans seems to have homologues of all of the elements of a functional pheromone response pathway involved in mating in S. cerevisiae but lacks many homologues of S. cerevisiae genes for meiosis. Other meiotic gene homologues in organisms ranging from filamentous fungi to Drosophila melanogaster and Caenorhabditis elegans were also found in the C. albicans genome, suggesting potential alternative mechanisms of genetic exchange.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.