ArticleProceedings of the National Academy of Sciences of the United States of America2001
Dissipative metabolic patterns respond during neutrophil transmembrane signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Elements of the cellular metabolic structure.Frontiers in molecular biosciences · 2015Article
- Article
- Sulfhydryl modification induces calcium entry through IP₃-sensitive store-operated pathway in activation-dependent human neutrophils.PloS one · 2011Article
- Quantitative analysis of cellular metabolic dissipative, self-organized structures.International journal of molecular sciences · 2010Review
- Oscillatory NAD(P)H waves and calcium oscillations in neutrophils? A modeling study of feasibility.Biophysical journal · 2009Article
- Fronts and pulses in an enzymatic reaction catalyzed by glucose oxidase.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression.Transactions of the American Ophthalmological Society · 2005Article
- Control of glycolytic oscillations by temperature.Biophysical journal · 2005Article
- Fluorescence spectroscopic detection of mitochondrial flavoprotein redox oscillations and transient reduction of the NADPH oxidase-associated flavoprotein in leukocytes.European biophysics journal : EBJ · 2004Article
- Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.The Journal of clinical investigation · 2002Article
- Shooting from the hip: spatial control of signal release by intracellular waves.Proceedings of the National Academy of Sciences of the United States of America · 2002Review
- Apparent role of traveling metabolic waves in oxidant release by living neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Molecular proximity of Kv1.3 voltage-gated potassium channels and beta(1)-integrins on the plasma membrane of melanoma cells: effects of cell adherence and channel blockers.The Journal of general physiology · 2002Article
- Interactions of integrins with their partner proteins in leukocyte membranes.Immunologic research · 2002Review
- Neutrophil oscillations: temporal and spatiotemporal aspects of cell behavior.Immunologic research · 2001Review
Corrections and comments
- Retraction · 2010-06-01Concerns/Issues about Data ·
- Retracted
- RetractedRetraction.2010
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Self-organization is a common theme in biology. One mechanism of self-organization is the creation of chemical patterns by the diffusion of chemical reactants and their nonlinear interactions. We have recently observed sustained unidirectional traveling chemical redox [NAD(P)H - NAD(P)(+)] waves within living polarized neutrophils. The present study shows that an intracellular metabolic wave responds to formyl peptide receptor agonists, but not antagonists, by splitting into two waves traveling in opposite directions along a cell's long axis. Similar effects were noted with other neutrophil-activating substances. Moreover, when cells were exposed to an N-formyl-methionyl-leucyl-phenylalanine (FMLP) gradient whose source was perpendicular to the cell's long axis, cell metabolism was locally perturbed with reorientation of the pattern in a direction perpendicular to the initial cellular axis. Thus, extracellular activating signals and the signals' spatial cues are translated into distinct intracellular dissipative structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.