ArticleProceedings of the National Academy of Sciences of the United States of America2001
A yeast-like mRNA capping apparatus in Plasmodium falciparum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- RNA triphosphatase-mediated mRNA capping is essential for maintaining transcript homeostasis and the survival of Toxoplasma gondii.Nature communications · 2025Article
- Architecture, domain organization, and functional signatures of trypanosomatid keIF4A1s andJournal of biosciences · 2023Article
- Identifying transcript 5' capped ends inPeerJ · 2021Article
- Crystal structures of the RNA triphosphatase fromThe Journal of biological chemistry · 2020Article
- Article
- A metazoan/plant-like capping enzyme and cap modified nucleotides in the unicellular eukaryote Trichomonas vaginalis.PLoS pathogens · 2010Article
- 5' and 3' end modifications of spliceosomal RNAs in Plasmodium falciparum.Molecular biology reports · 2010Article
- Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase.Nucleic acids research · 2009Article
- Polyphosphatase activity of CthTTM, a bacterial triphosphate tunnel metalloenzyme.The Journal of biological chemistry · 2008Article
- Evidence for a capping enzyme with specificity for the trypanosome spliced leader RNA.Molecular and biochemical parasitology · 2007Article
- Targeting purine and pyrimidine metabolism in human apicomplexan parasites.Current drug targets · 2007Review
- Structure-function analysis of Plasmodium RNA triphosphatase and description of a triphosphate tunnel metalloenzyme superfamily that includes Cet1-like RNA triphosphatases and CYTH proteins.RNA (New York, N.Y.) · 2006Article
- Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- What messenger RNA capping tells us about eukaryotic evolution.Nature reviews. Molecular cell biology · 2002Review
- Divergent subunit interactions among fungal mRNA 5'-capping machineries.Eukaryotic cell · 2002Article
- Review
- RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans.BMC microbiology · 2001Article
- The RNA capping machinery as an anti-infective target.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analysis of the mRNA capping apparatus of the malaria parasite Plasmodium falciparum illuminates an evolutionary connection to fungi rather than metazoans. We show that P. falciparum encodes separate RNA guanylyltransferase (Pgt1) and RNA triphosphatase (Prt1) enzymes and that the triphosphatase component is a member of the fungal/viral family of metal-dependent phosphohydrolases, which are structurally and mechanistically unrelated to the cysteine-phosphatase-type RNA triphosphatases found in metazoans and plants. These results highlight the potential for discovery of mechanism-based antimalarial drugs designed to specifically block the capping of Plasmodium mRNAs. A simple heuristic scheme of eukaryotic phylogeny is suggested based on the structure and physical linkage of the triphosphatase and guanylyltransferase enzymes that catalyze cap formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.