ReviewJournal of neuro-oncology
Models for assessment of angiogenesis in gliomas.
Review in Journal of neuro-oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Glioma angiogenesis is boosted by ELK3 activating the HIF-1BMC cancer · 2023Article
- Function of neuronal nitric oxide synthase enzyme in temozolomide-induced damage of astrocytic tumor cells.Oncology letters · 2018Article
- Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathway.Oncotarget · 2016Article
- Global Conservation of Protein Status between Cell Lines and Xenografts.Translational oncology · 2016Article
- Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma.PloS one · 2016Article
- Elevated cell invasion in a tumor sphere culture of RSV-M mouse glioma cells.Neurologia medico-chirurgica · 2015Article
- Characterization of the 9L gliosarcoma implanted in the Fischer rat: an orthotopic model for a grade IV brain tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Influence of levamisole and other angiogenesis inhibitors on angiogenesis and endothelial cell morphology in vitro.Cancers · 2013Article
- Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging.Journal of neuro-oncology · 2012Article
- MR imaging features of high-grade gliomas in murine models: how they compare with human disease, reflect tumor biology, and play a role in preclinical trials.AJNR. American journal of neuroradiology · 2012Review
- Peptide-based interference of the transmembrane domain of neuropilin-1 inhibits glioma growth in vivo.Oncogene · 2010Article
- Bioluminescent approaches for measuring tumor growth in a mouse model of neurofibromatosis.Toxicologic pathology · 2010Article
- High-resolution longitudinal assessment of flow and permeability in mouse glioma vasculature: Sequential small molecule and SPIO dynamic contrast agent MRI.Magnetic resonance in medicine · 2009Article
- Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth.Neoplasia (New York, N.Y.) · 2006Article
- Differential gene expression during capillary morphogenesis in a microcarrier-based three-dimensional in vitro model of angiogenesis with focus on chemokines and chemokine receptors.World journal of gastroenterology · 2005Article
- Expression of the thrombospondin 1 fragment 167-569 in C6 glioma cells stimulates tumorigenicity despite reduced neovascularization.Oncogene · 2004Article
- Influence of VEGF-R2 inhibition on MMP secretion and motility of microvascular human cerebral endothelial cells (HCEC).Journal of neuro-oncology · 2003Article
- Gene therapy for glioblastoma: future perspective for delivery systems and molecular targets.Cellular and molecular neurobiology · 2001Review
- Iron particles enhance visualization of experimental gliomas with high-resolution sonography.AJNR. American journal of neuroradiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last two decades, much attention has been focussed on mechanisms of glioma vascularization including the investigation of growth factors and receptors involved. Recently, these efforts resulted in various approaches for antiangiogenic treatment of experimental brain tumors. These basic science and preclinical trials need an assortment of models, which should allow investigating a variety of questions. Several objectives concerning basic endothelial cell (EC) characteristics can adequately be studied in vitro using EC monolayer assays. Three-dimensional spheroid techniques respect the more complex cell-cell and cell-environment interplay within a three-dimensional culture. To optimize the imitation of the crucial interaction of human gliomas with host endothelial cells, immunological cells and extracellular matrix, animal models are mandatory. An essential rule is to utilize an orthotopic model, since tumor-host interaction is organ specific. To avoid alloimmunogenic responses, it is desirable to use weakly or not immunogenic glioma grafts, what is best accomplished in a syngeneic model. However, since rat gliomas poorly resemble human glioma growth patterns, human glioma xenografting into immunocompromized animals should be considered. In vivo monitoring techniques like videoscopy via a cranial window or magnetic resonance imaging (MRI) allow for functional studies and improve the validity of the model employed. Finally, it is essentially to recognize the limitations of each model considered and to select that model, which seems to be most appropriate for the objectives to be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.