ArticleOncogene2001
Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 73 citations in OpenAlex.
- Viral Hepatitis and Hepatocellular Carcinoma: State of the Art.Pathogens (Basel, Switzerland) · 2021Review
- Article
- Synergistic Effect of MC-LR and C-Terminal Truncated HBx on HepG2 Cells and Their Effects on PP2A Mediated Downstream Target of MAPK Signaling Pathway.Frontiers in genetics · 2020Article
- Article
- Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice.Oncogene · 2014Article
- Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP.Molecular cancer · 2014Article
- Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line.International journal of cancer · 2010Article
- Liver cell transformation in chronic HBV infection.Viruses · 2009Article
- Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis.Medical molecular morphology · 2009Review
- Transformation of human liver L-O2 cells mediated by stable HBx transfection.Acta pharmacologica Sinica · 2009Article
- Dysregulation of apoptosis in hepatocellular carcinoma cells.World journal of gastroenterology · 2009Review
- Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma.Gut and liver · 2007Article
- Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells.Cancer science · 2007Article
- Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners.Journal of virology · 2007Article
- Molecular functions and biological roles of hepatitis B virus x protein.Cancer science · 2006Review
- Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein.World journal of gastroenterology · 2006Article
- Chronic hepatitis B in hepatocarcinogenesis.Postgraduate medical journal · 2006Review
- Transfection and expression of hepatitis B virus x gene and its effect on apoptosis in HL-7702 cells.World journal of gastroenterology · 2004Article
- Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis.BMC gastroenterology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hepatitis B virus HBx protein is a promiscuous transactivator implicated in the development of hepatocellular carcinoma. The ectopic expression of HBx fails to transform both primary and immortalized rodent cells, but rather induces apoptosis. Furthermore, most transgenic mice harboring HBx do not develop liver tumors. Thus, it remains unclear whether and how HBx contributes to oncogenesis. Here, we show that HBx collaborates with activated H-ras to transform immortalized rodent cells. Indeed, REF52 cells transfected by both HBx and activated H-ras were morphologically transformed and were able to grow in soft agar. Remarkably, nude mice injected with REF52 cells transfected by both HBx and activated H-ras developed tumors, whereas the mice injected with REF52 cells transfected by either gene alone did not. Thus, we concluded that HBx could contribute to neoplastic transformation of cells in collaboration with other oncogenes, such as H-ras, that renders cells to overcome the HBx-mediated apoptosis. Further, we found that HBx mediated apoptosis was suppressed by activated H-ras through activation of the phosphatidylinositol-3 kinase and Akt pathway. Data presented here firmly established the oncogenic potential of HBx during multistage carcinogenesis. Oncogene (2001) 20, 16 - 23.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.