ArticlePlant physiology2001
Role of mRNA secondary structure in translational repression of the maize transcriptional activator Lc(1,2).
Article in Plant physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- From Structure to Function of Promoters and 5'UTRs in Maize.International journal of molecular sciences · 2026Review
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- Analysis of Thioredoxins and Glutaredoxins in Soybean: Evidence of Translational Regulation under Water Restriction.Antioxidants (Basel, Switzerland) · 2022Article
- Piperine analogs arrest c-myc gene leading to downregulation of transcription for targeting cancer.Scientific reports · 2021Article
- Climate change shapes the future evolution of plant metabolism.Advanced genetics (Hoboken, N.J.) · 2020Article
- The mitoribosome-specific protein mS38 is preferentially required for synthesis of cytochrome c oxidase subunits.Nucleic acids research · 2019Article
- Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing.Frontiers in immunology · 2019Article
- Complex regulation of the TaMyc1 gene expression in wheat grain synthesizing anthocyanin pigments.Molecular biology reports · 2018Article
- Genetic editing and interrogation with Cpf1 and caged truncated pre-tRNA-like crRNA in mammalian cells.Cell discovery · 2018Article
- Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels.Nucleic acids research · 2017Article
- The Conservation and Function of RNA Secondary Structure in Plants.Annual review of plant biology · 2016Review
- Transcriptome-wide measurement of plant RNA secondary structure.Current opinion in plant biology · 2015Review
- Aminoacylation of Plasmodium falciparum tRNA(Asn) and insights in the synthesis of asparagine repeats.The Journal of biological chemistry · 2013Article
- Translational Regulation of Cytoplasmic mRNAs.The arabidopsis book · 2013Article
- Arabidopsis ribosomal proteins control developmental programs through translational regulation of auxin response factors.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Re-engineering multicloning sites for function and convenience.Nucleic acids research · 2011Article
- Determinants of translation efficiency and accuracy.Molecular systems biology · 2011Review
- An Ebox element in the proximal Gata4 promoter is required for Gata4 expression in vivo.PloS one · 2011Article
- Post-transcriptional regulation of gene expression in plants during abiotic stress.International journal of molecular sciences · 2009Review
- Conserved upstream open reading frames in higher plants.BMC genomics · 2008Article
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2 authors.
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Abstract
Lc, a member of the maize (Zea mays) R/B gene family, encodes a basic helix-loop-helix transcriptional activator of the anthocyanin biosynthetic pathway. It was previously shown that translation of the Lc mRNA is repressed by a 38-codon upstream open reading frame (uORF) in the 5' leader. In this study, we report that a potential hairpin structure near the 5'end of the Lc mRNA also represses downstream translation in the rabbit reticulocyte in vitro translation system and in transient transformation assays. Base pairing of the hairpin is important for repression because its destabilization increases translation of the uORF and the downstream ORF. However, translation of the uORF is not required for the hairpin-mediated repression. Instead, the uORF and the 5'-proximal hairpin mediate two independent levels of repression. Although the uORF represses downstream translation due to inefficient reinitiation of ribosomes that translate uORF, the hairpin inhibits ribosome loading at the 5' end of the mRNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.