ArticleCell growth & differentiation : the molecular biology journal of the American Association for Cancer Research2001
DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia.
Article in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Old versus new: upstream and downstream of promyelocytic leukemia zinc finger protein.Cancer gene therapy · 2025Review
- Interaction with RXR is necessary for NPM-RAR-induced myeloid differentiation blockade.Leukemia research · 2013Article
- A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.The Journal of biological chemistry · 2011Article
- Characterisation of genome-wide PLZF/RARA target genes.PloS one · 2011Article
- DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified.Molecular and cellular endocrinology · 2010Article
- Estrogen receptors recruit SMRT and N-CoR corepressors through newly recognized contacts between the corepressor N terminus and the receptor DNA binding domain.Molecular and cellular biology · 2010Article
- Article
- Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells.Biochemical pharmacology · 2008Article
- Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemia.Oncogene · 2006Article
- In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.The Journal of experimental medicine · 2006Article
- Article
- Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties.Molecular endocrinology (Baltimore, Md.) · 2005Article
- Article
- PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation.The Journal of experimental medicine · 2004Article
- Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression.Molecular and cellular biology · 2003Article
- Variations on a theme: the alternate translocations in APL.Leukemia · 2002Review
- Review
- Do parents of children with congenital malformations have a higher cancer risk? A nationwide study in Denmark.British journal of cancer · 2002Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Human acute promyelocytic leukemias (APLs) are associated with chromosomal translocations that replace the NH2 terminus of wild-type retinoic acid receptor (RAR) alpha with portions of the promyelocytic leukemia protein (PML) or promyelocytic leukemia zinc-finger protein (PLZF). The wild-type RARalpha readily forms heterodimers with the retinoid X receptors (RXRs), and these RAR/RXR heterodimers appear to be the principal mediators of retinoid signaling in normal cells. In contrast, PML-RARalpha and PLZF-RARa display an enhanced ability to form homodimers, and this enhanced homodimer formation is believed to contribute to the neoplastic properties of these chimeric oncoproteins. We report here that the DNA recognition specificity of the RXRalpha/RARa heterodimer, which is presumed to be the dominant receptor species in normal cells, differs from that of the PML-RARalpha and PLZF-RARalpha homodimers, which are thought to prevail in the oncogenic cell. We suggest that differences in target gene recognition by the normal and oncogenic RARalpha proteins may contribute to the leukemogenic phenotype.
Indexed as
Identifiers
11243468PMC2712924W2136638106What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.