ArticleNucleic acids research2001
Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Innate inflammation in type 1 diabetes.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.Genetics · 2015Article
- Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.Mediators of inflammation · 2015Review
- Gimap and T cells: a matter of life or death.European journal of immunology · 2014Article
- Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes.Genes and immunity · 2013Article
- Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells.The Journal of experimental medicine · 2011Article
- Gimap3 regulates tissue-specific mitochondrial DNA segregation.PLoS genetics · 2010Article
- Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat.Diabetes · 2010Article
- GIMAP Proteins in T-Lymphocytes.Journal of signal transduction · 2010Article
- Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.Malaria journal · 2009Article
- IAN/GIMAPs are conserved and novel regulators in vertebrates and angiosperm plants.Plant signaling & behavior · 2009Review
- CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.PloS one · 2009Article
- Sequence variation and expression of the Gimap gene family in the BB rat.Experimental diabetes research · 2009Article
- Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.The Journal of biological chemistry · 2008Article
- IAN family critically regulates survival and development of T lymphocytes.PLoS biology · 2006Article
- Article
- p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells.Leukemia · 2004Article
- hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies.Genes and immunity · 2004Article
- Ian4 is required for mitochondrial integrity and T cell survival.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Using the representation difference analysis technique, we have identified a novel gene, Ian4, which is preferentially expressed in hematopoietic precursor 32D cells transfected with wild-type versus mutant forms of the Bcr/Abl oncogene. Ian4 expression was undetectable in 32D cells transfected with v-src, oncogenic Ha-ras or v-Abl. Murine Ian4 maps to chromosome 6, 25 cM from the centromere. The Ian4 mRNA contains two open reading frames (ORFs) separated by 5 nt. The first ORF has the potential to encode for a polypeptide of 67 amino acids without apparent homology to known proteins. The second ORF encodes a protein of 301 amino acids with a GTP/ATP-binding site in the N-terminus and a hydrophobic domain in the extreme C-terminus. The IAN-4 protein resides in the mitochondrial outer membrane and the last 20 amino acids are necessary for this localization. The IAN-4 protein has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family.
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