ReviewMicrobiology and molecular biology reviews : MMBR2001
Biosynthesis of polyketides in heterologous hosts.
Review in Microbiology and molecular biology reviews : MMBR, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- Toward Complex Polyketide Biosynthesis inJournal of microbiology and biotechnology · 2026Review
- EngineeringMetabolic engineering communications · 2025Article
- Engineering a carbon source-responsive promoter for improved biosynthesis in the non-conventional yeastMetabolic engineering communications · 2024Article
- Bacillamide D produced by Bacillus cereus from the mouse intestinal bacterial collection (miBC) is a potent cytotoxin in vitro.Communications biology · 2024Article
- Impact of Exposure to a Mixture of Organophosphate Esters on Adrenal Cell Phenotype, Lipidome, and Function.Endocrinology · 2024Article
- Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies.ACS synthetic biology · 2023Article
- Genomic mining and diversity of assembly line polyketide synthases.Open biology · 2023Article
- Detection of Antagonistic Compounds Synthesized byMicroorganisms · 2023Article
- Enhanced production of acetyl-CoA-based products via peroxisomal surface display inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli.Microbial biotechnology · 2022Article
- A roadmap for metagenomic enzyme discovery.Natural product reports · 2021Review
- Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides.Microbial cell factories · 2021Review
- Biotransformation of Benzoate to 2,4,6-Trihydroxybenzophenone by EngineeredMolecules (Basel, Switzerland) · 2021Article
- ActDES - a curated Actinobacterial Database for Evolutionary Studies.Microbial genomics · 2021Article
- Review
- Natural Polypropionates in 1999-2020: An Overview of Chemical and Biological Diversity.Marine drugs · 2020Review
- Heterologous Expression of the Core Genes in the Complex Fusarubin Gene Cluster ofInternational journal of molecular sciences · 2020Article
- Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases.Journal of the American Chemical Society · 2020Article
- Fatty Acid Synthase Beta Dehydratase in the Lipid Biosynthesis Pathway Is Required for Conidiogenesis, Pigmentation and Appressorium Formation inInternational journal of molecular sciences · 2020Article
- In Silico Identification of Type III PKS Chalcone and Stilbene Synthase Homologs in Marine Photosynthetic Organisms.Biology · 2020Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Polyketide natural products show great promise as medicinal agents. Typically the products of microbial secondary biosynthesis, polyketides are synthesized by an evolutionarily related but architecturally diverse family of multifunctional enzymes called polyketide synthases. A principal limitation for fundamental biochemical studies of these modular megasynthases, as well as for their applications in biotechnology, is the challenge associated with manipulating the natural microorganism that produces a polyketide of interest. To ameliorate this limitation, over the past decade several genetically amenable microbes have been developed as heterologous hosts for polyketide biosynthesis. Here we review the state of the art as well as the difficulties associated with heterologous polyketide production. In particular, we focus on two model hosts, Streptomyces coelicolor and Escherichia coli. Future directions for this relatively new but growing technological opportunity are also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.