ArticleMolecular and cellular biology2001
The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4+ and CD8+ T Cells, and Skin Mast Cells by Quantitative Transcriptomics.International journal of molecular sciences · 2024Article
- The Role of the Transcriptional Coactivator BOB.1/OBF.1 in Adaptive Immunity.Advances in experimental medicine and biology · 2024Review
- The transcriptional program during germinal center reaction - a close view at GC B cells, Tfh cells and Tfr cells.Frontiers in immunology · 2023Review
- A broad and systematic approach to identify B cell malignancy-targeting TCRs for multi-antigen-based T cell therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation.Frontiers in immunology · 2022Article
- Differential Requirement of Vav Proteins for Btk-dependent and -Independent Signaling During B Cell Development.Frontiers in cell and developmental biology · 2022Article
- Effect of antipyretic analgesics on immune responses to vaccination.Human vaccines & immunotherapeutics · 2016Review
- The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.The EMBO journal · 2016Article
- Oct2 and Obf1 as Facilitators of B:T Cell Collaboration during a Humoral Immune Response.Frontiers in immunology · 2014Article
- A C-terminal acidic domain regulates degradation of the transcriptional coactivator Bob1.Molecular and cellular biology · 2013Article
- Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB.Nucleic acids research · 2013Article
- B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1.Current topics in microbiology and immunology · 2012Review
- Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication.Molecular cell · 2011Article
- Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development.PloS one · 2008Article
- Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.European journal of immunology · 2008Article
- BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses.The EMBO journal · 2007Article
- Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.Blood · 2006Article
- The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Btk expression is controlled by Oct and BOB.1/OBF.1.Nucleic acids research · 2006Article
- Differential requirement for OBF-1 during antibody-secreting cell differentiation.The Journal of experimental medicine · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcriptional coactivator BOB.1/OBF.1 confers B-cell specificity on the transcription factors Oct1 and Oct2 at octamer site-containing promoters. A hallmark of the BOB.1/OBF.1 mutation in the mouse is the absence of germinal center development in secondary lymphoid organs, demonstrating the requirement for BOB.1/OBF.1 in antigen-dependent stages of B-cell differentiation. Here we analyzed earlier stages of B lymphopoiesis in BOB.1/OBF.1-deficient mice. Examination of B-cell development in the bone marrow revealed that the numbers of transitional immature (B220(+) IgM(hi)) B cells were reduced and that B-cell apoptosis was increased. When in competition with wild-type cells, BOB.1/OBF.1(-/-) bone marrow cells exhibited defects in repopulating the bone marrow B-cell compartment and were unable to establish a presence in the periphery of host mice. The defective bone marrow populations in BOB.1/OBF.1(-/-) mice were rescued by conditional expression of a BOB.1/OBF.1 transgene controlled by the tetracycline gene expression system. However, the restored populations did not restore the numbers of IgD(hi) B cells in the periphery, where the BOB.1/OBF.1 transgene was not expressed. These results show that BOB.1/OBF.1(-/-) B cells exhibit multistage defects in B-cell development, including impaired production of transitional B cells and defective maturation of recirculating B cells.
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