ArticleJournal of virology2001
Human immunodeficiency virus seroconversion and evolution of the hepatitis C virus quasispecies.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Hepatitis C Virus (HCV) NS3 sequence diversity and antiviral resistance-associated variant frequency in HCV/HIV coinfection.Antimicrobial agents and chemotherapy · 2014Article
- Evaluation of rapid progressors in HIV infection as an extreme phenotype.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Evidence of distinct populations of hepatitis C virus in the liver and plasma of patients co-infected with HIV and HCV.Journal of medical virology · 2014Article
- Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses.Hepatology (Baltimore, Md.) · 2014Article
- Vertical transmission of hepatitis C virus: a tale of multiple outcomes.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission.Journal of clinical microbiology · 2012Article
- Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence.Immunologic research · 2010Review
- Understanding the molecular epidemiology of foot-and-mouth-disease virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Review
- Genetic divergence of hepatitis C virus: the role of HIV-related immunosuppression.Journal of acquired immune deficiency syndromes (1999) · 2008Article
- Trends for genetic variation of Hepatitis C Virus quasispecies in Human Immunodeficiency virus-1 coinfected patients.Virus research · 2007Article
- Hepatitis C virus quasispecies in HIV-infected women: role of injecting drug use and highly active antiretroviral therapy (HAART).Hepatology (Baltimore, Md.) · 2007Article
- Factors affecting serum concentrations of hepatitis C virus (HCV) RNA in HCV genotype 1-infected patients with chronic hepatitis.Journal of clinical microbiology · 2007Article
- Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis.Virology journal · 2005Article
- Accurate representation of the hepatitis C virus quasispecies in 5.2-kilobase amplicons.Journal of clinical microbiology · 2004Article
- Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1.Journal of clinical microbiology · 2004Article
- Impact of highly active antiretroviral therapy and immunologic status on hepatitis C virus quasispecies diversity in human immunodeficiency virus/hepatitis C virus-coinfected patients.Journal of virology · 2003Article
- Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
When chronic hepatitis C virus (HCV) infections are complicated by acquisition of human immunodeficiency virus (HIV), liver disease appears to accelerate and serum levels of HCV RNA may rise. We hypothesized that HIV might affect the HCV quasispecies by decreasing both complexity (if HIV-induced immunosuppression lessens pressure for selecting HCV substitutions) and the ratio of nonsynonymous (d(N)) to synonymous (d(S)) substitutions, because d(N) may be lower (if there is less selective pressure). To test this hypothesis, we studied the evolution of HCV sequences in 10 persons with chronic HCV infection who seroconverted to HIV and, over the next 3 years, had slow or rapid progression of HIV-associated disease. From each subject, four serum specimens were selected with reference to HIV seroconversion: (i) more than 2 years prior, (ii) less than 2 years prior, (iii) less than 2 years after, and (iv) more than 2 years after. The HCV quasispecies in these specimens was characterized by generating clones containing 1 kb of cDNA that spanned the E1 gene and the E2 hypervariable region 1 (HVR1), followed by analysis of clonal frequencies (via electrophoretic migration) and nucleotide sequences. We examined 1,320 cDNA clones (33 per time point) and 287 sequences (median of 7 per time point). We observed a trend toward lower d(N)/d(S) after HIV seroconversion in 7 of 10 subjects and lower d(N)/d(S) in those with rapid HIV disease progression. However, the magnitude of these differences was small. These results are consistent with the hypothesis that HIV infection alters the HCV quasispecies, but the number of subjects and observation time may be too low to characterize the full effect.
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