ArticleThe Journal of experimental medicine2001
Antiviral CD8+ T cell responses in neonatal mice: susceptibility to polyoma virus-induced tumors is associated with lack of cytotoxic function by viral antigen-specific T cells.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
- An Elusive Target: Inhibitors of JC Polyomavirus Infection and Their Development as Therapeutics for the Treatment of Progressive Multifocal Leukoencephalopathy.International journal of molecular sciences · 2023Review
- Understanding polyomavirus CNS disease - a perspective from mouse models.The FEBS journal · 2022Review
- TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection.PLoS pathogens · 2017Article
- Type I Interferons Regulate the Magnitude and Functionality of Mouse Polyomavirus-Specific CD8 T Cells in a Virus Strain-Dependent Manner.Journal of virology · 2016Article
- Gamma interferon controls mouse polyomavirus infection in vivo.Journal of virology · 2011Article
- T-cell exhaustion: characteristics, causes and conversion.Immunology · 2010Review
- Shaping successful and unsuccessful CD8 T cell responses following infection.Journal of biomedicine & biotechnology · 2010Review
- Immunity to polyomavirus infection: the polyomavirus-mouse model.Seminars in cancer biology · 2009Review
- Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- An MHC class Ib-restricted CD8 T cell response confers antiviral immunity.The Journal of experimental medicine · 2008Article
- Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiation.Journal of virology · 2007Article
- Interferon-gamma is produced by CD8 T cells in response to HLA-A24-restricted hepatitis C virus epitopes after sustained virus loss.Clinical and experimental immunology · 2005Article
- Memory CD8 T-cell differentiation during viral infection.Journal of virology · 2004Review
- Pathogen-host standoff: immunity to polyomavirus infection and neoplasia.Immunologic research · 2004Review
- Plasticity of T cell memory responses to viruses.Immunity · 2004Review
- Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite.The Journal of experimental medicine · 2003Article
- Hantavirus-specific CD8(+)-T-cell responses in newborn mice persistently infected with Hantaan virus.Journal of virology · 2003Article
- Activation of tumor antigen-specific cytotoxic T lymphocytes (CTLs) by human dendritic cells infected with an attenuated influenza A virus expressing a CTL epitope derived from the HER-2/neu proto-oncogene.Journal of virology · 2003Article
- Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function.The Journal of experimental medicine · 2003Article
- Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccines.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Polyoma virus is a potent oncogenic pathogen when inoculated into newborn mice of particular H-2(k) strains. Using D(k) tetramers containing the dominant antipolyoma CD8(+) T cell epitope, middle T protein (MT)389-397, and intracellular interferon gamma staining, we enumerated MT389-specific CD8(+) T cells in infected neonates having opposite susceptibilities to polyoma virus-induced tumors. In resistant mice, MT389-specific CD8(+) T cells dramatically expanded during acute infection in neonates to a frequency rivaling that in adults; furthermore, in both neonatal and adult mice, this antipolyoma CD8(+) T cell response exhibited nearly identical T cell receptor (TCR) functional avidities and TCR functional fingerprints. Susceptible mice mounted an MT389-specific CD8(+) T cell response of only fourfold lower magnitude than resistant mice; but, in clear contrast to resistant mice, these CD8(+) T cells lacked ex vivo MT389-specific cytotoxic activity. However, MT389-specific CD8(+) T cells in resistant and susceptible mice expressed similar TCR avidities, perforin levels, and surface type O-glycan levels indicative of mature CD8(+) T cell effectors. Upon in vitro restimulation with infected antigen-presenting cells, CD8(+) T cells from acutely infected susceptible neonates acquired strong MT389-specific cytotoxicity. These findings indicate that polyoma-specific CD8(+) T cells are armed with, but restrained from deploying, their cytotoxic effector function in mice susceptible to polyoma virus tumorigenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.