ArticleGenetics2001
The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Time to match; when do homologous chromosomes become closer?Chromosoma · 2022Article
- A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11.Chromosoma · 2016Article
- Comparative genome analysis of Pseudogymnoascus spp. reveals primarily clonal evolution with small genome fragments exchanged between lineages.BMC genomics · 2015Article
- Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.Cell reports · 2014Article
- Repair of strand breaks by homologous recombination.Cold Spring Harbor perspectives in biology · 2013Review
- Numerical constraints and feedback control of double-strand breaks in mouse meiosis.Genes & development · 2013Article
- How to halve ploidy: lessons from budding yeast meiosis.Cellular and molecular life sciences : CMLS · 2012Review
- RNA methylation by the MIS complex regulates a cell fate decision in yeast.PLoS genetics · 2012Article
- Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling.PLoS genetics · 2012Article
- Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants.PLoS biology · 2011Article
- Phospholipase D: enzymology, functionality, and chemical modulation.Chemical reviews · 2011Review
- Cell cycle regulation of DNA replication.Annual review of genetics · 2007Review
- Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe.Chromosoma · 2006Article
- Review
- The Arf-GTPase-activating protein Gcs1p is essential for sporulation and regulates the phospholipase D Spo14p.Eukaryotic cell · 2006Article
- Novel response to microtubule perturbation in meiosis.Molecular and cellular biology · 2005Article
- Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Parental origin and timing of de novo Robertsonian translocation formation.American journal of human genetics · 2002Review
- Meiotic deletion at the BUF1 locus of the fungus Magnaporthe grisea is controlled by interaction with the homologous chromosome.Genetics · 2002Article
- Meiotic recombination frequencies are affected by nutritional states in Saccharomycescerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
The Saccharomyces cerevisiae MUM2 gene is essential for meiotic, but not mitotic, DNA replication and thus sporulation. Genetic interactions between MUM2 and a component of the origin recognition complex and polymerase alpha-primase suggest that MUM2 influences the function of the DNA replication machinery. Early meiotic gene expression is induced to a much greater extent in mum2 cells than in meiotic cells treated with the DNA synthesis inhibitor hydroxyurea. This result indicates that the mum2 meiotic arrest is downstream of the arrest induced by hydroxyurea and suggests that DNA synthesis is initiated in the mutant. Genetic analyses indicate that the recombination that occurs in mum2 mutants is dependent on the normal recombination machinery and on synaptonemal complex components and therefore is not a consequence of lesions created by incompletely replicated DNA. Both meiotic ectopic and allelic recombination are similarly reduced in the mum2 mutant, and the levels are consistent with the levels of meiosis-specific DSBs that are generated. Cytological analyses of mum2 mutants show that chromosome pairing and synapsis occur, although at reduced levels compared to wild type. Given the near-wild-type levels of meiotic gene expression, pairing, and synapsis, we suggest that the reduction in DNA replication is directly responsible for the reduced level of DSBs and meiotic recombination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.