ArticleClinical and diagnostic laboratory immunology2001
Butyric acid-induced T-cell apoptosis is mediated by caspase-8 and -9 activation in a Fas-independent manner.
Article in Clinical and diagnostic laboratory immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- The Role of Short-Chain Fatty Acids Produced by Oral Bacteria in Modulating Oral Immunity.Advances in experimental medicine and biology · 2026Review
- Time-Dependent Changes in Effects of Butyrate on Human Gingival Fibroblasts.Clinical and experimental dental research · 2025Article
- Monocyte-Platelet Aggregates Are Major Source of BDNF after Bacterial Stimulation of Human Peripheral Blood Immune Cells.European journal of immunology · 2025Article
- The role of intestinal microbiota and its metabolite short-chain fatty acids in hypertriglyceridemia-associated acute pancreatitis.Frontiers in microbiology · 2025Review
- The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.PLoS biology · 2023Article
- Article
- Gut microbial-derived short-chain fatty acids and bone: a potential role in fracture healing.European cells & materials · 2021Review
- Article
- Relationship between periodontal disease and butyric acid produced by periodontopathic bacteria.Inflammation and regeneration · 2018Review
- Odorous Compounds from Poultry Manure Induce DNA Damage, Nuclear Changes, and Decrease Cell Membrane Integrity in Chicken Liver Hepatocellular Carcinoma Cells.International journal of environmental research and public health · 2017Article
- Diabetes Mellitus and Increased Tuberculosis Susceptibility: The Role of Short-Chain Fatty Acids.Journal of diabetes research · 2016Article
- Regulation of inflammation by short chain fatty acids.Nutrients · 2011Review
- Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis.Frontiers in bioscience : a journal and virtual library · 2008Review
- Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells.Infection and immunity · 2005Article
- Role of cell-cell communication in inhibiting butyric acid-induced T-cell apoptosis.Infection and immunity · 2004Article
- Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous study demonstrated that butyric acid, an extracellular metabolite of periodontopathic bacteria, induced apoptosis in murine thymocytes, splenic T cells, and human Jurkat cells. In this study, we examined whether CD95 ligand-receptor interaction is involved in butyric acid-induced T-cell apoptosis. Flow cytometry analysis indicated that expression of Fas in Jurkat and T cells from peripheral blood mononuclear cells was not affected by butyric acid treatment. Furthermore, the expression of Fas and FasL protein in Western blotting was not affected by butyric acid treatment. Coincubation with blocking anti-Fas antibodies prevented Fas-induced apoptosis but not butyric acid-induced apoptosis. Anti-FasL antibodies also did not prevent butyric acid-induced apoptosis at any dose examined. Although cytotoxic anti-Fas antibody affected butyric acid-induced apoptosis, a synergistic effect was not seen. Time-dependent activation of caspase-8 and -9 was recognized in butyric acid- as well as Fas-mediated apoptosis. IETD-CHO and LEHD-CHO, specific inhibitors of caspase-8 and -9, respectively, completely blocked Fas-mediated apoptosis and partially prevented butyric acid-induced apoptosis. These results suggest that the Fas-FasL interaction is not involved in butyric acid-induced apoptosis and that caspase-8 and -9-dependent apoptosis plays an important role in butyric acid-induced apoptosis, as well as Fas-induced apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.