ArticleThe American journal of pathology2001
Basic fibroblast growth factor and ultraviolet B transform melanocytes in human skin.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 82 citations in OpenAlex.
- HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma.International journal of molecular sciences · 2022Article
- A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue.Cancers · 2020Review
- Review
- Palladium based nanoparticles for the treatment of advanced melanoma.Scientific reports · 2019Article
- Alleviation of Ultraviolet-B Radiation-Induced Photoaging by a TNFR Antagonistic Peptide, TNFR2-SKE.Molecules and cells · 2019Article
- SOX10 promotes melanoma cell invasion by regulating melanoma inhibitory activity.The Journal of investigative dermatology · 2014Article
- Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.Antioxidants & redox signaling · 2013Article
- Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas.The Journal of investigative dermatology · 2013Article
- FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription.Cell death and differentiation · 2012Article
- Prognostic parameters for the primary care of melanoma patients: what is really risky in melanoma?Journal of skin cancer · 2011Article
- Expression of fibroblast growth factor binding protein in head and neck cancer.Archives of otolaryngology--head & neck surgery · 2009Article
- Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.BMC cancer · 2009Article
- The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes.The American journal of pathology · 2009Article
- CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1.The Journal of cell biology · 2006Article
- FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients.British journal of cancer · 2006Article
- Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression.The Journal of clinical investigation · 2005Article
- Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V 600 E) B-RAF.Oncogene · 2005Article
- p53 alone or in combination with antisense cyclin D1 induces apoptosis and reduces tumor size in human melanoma.Cancer gene therapy · 2002Article
- Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE.Oncogene · 2002Article
- Importance of vascular phenotype by basic fibroblast growth factor, and influence of the angiogenic factors basic fibroblast growth factor/fibroblast growth factor receptor-1 and ephrin-A1/EphA2 on melanoma progression.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Ultraviolet (UV) light is an epidemiological risk factor for melanoma, but its specific contribution to melanoma induction is not known. The first critical step of melanoma development, ie, the uncontrolled proliferation of melanocytes, may be induced by a combination of UV damage and an imbalance of growth factor production by cells in the immediate area of the melanocyte. Among several candidates, basic fibroblast growth factor (bFGF) is the major autocrine growth factor in melanoma and associated with tumor progression. Overexpression of bFGF via adenoviral gene transfer in human skin xenografted to severe combined immunodeficiency mice led to black-pigmented macules within 3 weeks of treatment. Immunofluorescence analysis demonstrated pathological hyperpigmentation, proliferation and hyperplasia of activated melanocytes, but no malignant transformation. Similar changes were observed in skin reconstructs. When bFGF was combined with UVB, pigmented lesions with hyperplastic melanocytic cells were detected, including a lesion with high-grade atypia resembling lentiginous forms of malignant melanoma. Donor-matched control grafts revealed no melanocytic changes. bFGF was overexpressed in dermal fibroblasts demonstrating the co-carcinogenic influence of paracrine-acting growth factors by cells of the microenvironment. This is the first report suggesting that an imbalance of physiological growth factor production in the skin may cause melanoma in combination with UVB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.