ArticleThe American journal of pathology2001
Expression of the intermediate filament nestin in gastrointestinal stromal tumors and interstitial cells of Cajal.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 92 citations in OpenAlex.
- PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percreta†.Biology of reproduction · 2021Article
- Clinicopathological and prognostic significance of nestin expression in patients with breast cancer: a systematic review and meta-analysis.Cancer cell international · 2020Article
- Clinical Diagnosis of Gastrointestinal Stromal Tumor (GIST): From the Molecular Genetic Point of View.Cancers · 2019Review
- Nestin regulates proliferation and invasion of gastrointestinal stromal tumor cells by altering mitochondrial dynamics.Oncogene · 2016Article
- Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors.International journal of clinical and experimental pathology · 2015Article
- Nestin involvement in tissue injury and cancer--a potential tumor marker?Cellular oncology (Dordrecht, Netherlands) · 2014Review
- Expression and role of nestin in human cervical intraepithelial neoplasia and cervical cancer.International journal of oncology · 2012Article
- Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis.World journal of gastroenterology · 2011Review
- Gastrointestinal stromal tumors (GISTs): an updated experience.Digestive diseases and sciences · 2010Review
- Plexiform angiomyxoid myofibroblastic tumor of the stomach.World journal of gastroenterology · 2010Review
- Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2010Article
- Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression.BMC neuroscience · 2009Article
- Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer.Human pathology · 2009Article
- Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines.BMC cancer · 2008Article
- Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor.Medical molecular morphology · 2008Article
- Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis.Cancer research · 2007Article
- Microfluidic deletion/insertion analysis for rapid screening of KIT and PDGFRA mutations in CD117-positive gastrointestinal stromal tumors: diagnostic applications and report of a new KIT mutation.The Journal of molecular diagnostics : JMD · 2007Article
- Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach.The Journal of clinical investigation · 2007Review
- Gastrointestinal stromal tumor (GIST).Current treatment options in gastroenterology · 2006Article
- Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has recently been proposed that gastrointestinal stromal tumors (GISTs) originate from stem cells that differentiate toward a phenotype of interstitial cells of Cajal (ICCs). Nestin is a newly identified intermediate filament protein, and is predominantly expressed in immature cells, such as neuroectodermal stem cells and skeletal muscle progenitor cells, and tumors originating from these cells. In this study, we examined, using immunohistochemistry, the nestin expression in GISTs and ICCs to clarify the origin of GISTs. Strong immunoreactivity for nestin was observed in all 18 GISTs, and its expression was confirmed by Western blot and Northern blot analyses. In contrast, three leiomyomas and a schwannoma that developed in the gastrointestinal tract showed no apparent immunoreactivity for nestin. Among 17 mesenchymal tumors (seven leiomyosarcomas, five malignant peripheral nerve sheath tumors, and five fibrosarcomas) that occurred in sites other than the gastrointestinal tract, only two malignant peripheral nerve sheath tumors were moderately immunoreactive for nestin. Furthermore, with fluorescence double immunostaining of the normal small intestine, nestin expression was demonstrated in ICCs. These results show that nestin may be a useful marker for diagnosis of GISTs, and support the current hypothesis that GISTs are tumors of stem cells that differentiate toward an ICC phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.