ArticleThe Biochemical journal2001
Increased inwardly rectifying potassium currents in HEK-293 cells expressing murine transient receptor potential 4.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Acid-sensing ion channels interact with and inhibit BK K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Insights on TRP channels from in vivo studies in Drosophila.Annual review of physiology · 2006Review
- Homo- and heteromeric assembly of TRP channel subunits.Pflugers Archiv : European journal of physiology · 2005Article
- Expression and functional evaluation of transient receptor potential channel 4 in bovine corneal endothelial cells.Experimental eye research · 2005Article
- Receptor-operated cation channels formed by TRPC4 and TRPC5.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila transient receptor potential (Trp) and its mammalian homologues are postulated to form capacitative Ca2+ entry or store-operated channels. Here we show that expression of murine Trp4 in HEK 293 cells also leads to an increase in inwardly rectifying K+ currents. No similar increase was found in cell lines expressing Trp1, Trp3 or Trp6. Consistent with typical characteristics of inward rectifiers, the K+ currents in Trp4-expressing cells were blocked by low millimolar concentrations of Cs+ and Ba2+, but not by 1.2 mM Ca2+, and were only slightly inhibited by 5 mM tetraethylammonium. Single channel recordings of excised inside-out patches revealed the presence of two conducting states of 51 pS and 94 pS in Trp4-expressing cells. The outward current in the excised patches was blocked by 1 mM spermine, but not by 1 mM Mg2+. How Trp4 expression causes the increase in the K+ currents is not known. We propose that Trp4 either participates in the formation of a novel K+ channel or up-regulates the expression or activity of endogenous inwardly rectifying K+ channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.