ArticleThe Biochemical journal2001
Epicatechin and its in vivo metabolite, 3'-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07149506 (Efficacy of Oral or Topical Catechins vs. Placebo as an Adjuvant for the Prevention and Management of Radiation Dermatitis in Oncology Patients), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Oral or Topical Catechins vs. Placebo as an Adjuvant for the Prevention and Management of Radiation Dermatitis in Oncology Patients: a Randomized Trial
Who cites it
29 citing papers in PubMed, 177 citations in OpenAlex.
- Epigallocatechin Gallate From Tea Delays Oocyte Aging After Ovulation in Mice.Food science & nutrition · 2026Article
- Chemical Composition, Antioxidant Activity and Cytocompatibility of Polyphenolic Compounds Extracted from Food Industry Apple Waste: Potential in Biomedical Application.Molecules (Basel, Switzerland) · 2023Article
- Catechins: Protective mechanism of antioxidant stress in atherosclerosis.Frontiers in pharmacology · 2023Review
- Nano Ag/CoPolymers · 2022Article
- Neuroprotective Effects and Therapeutic Potential of the Citrus Flavonoid Hesperetin in Neurodegenerative Diseases.Nutrients · 2022Review
- Can Polyphenols Inhibit Ferroptosis?Antioxidants (Basel, Switzerland) · 2022Review
- A Common Feature of Pesticides: Oxidative Stress-The Role of Oxidative Stress in Pesticide-Induced Toxicity.Oxidative medicine and cellular longevity · 2022Review
- Naringin Supplementation during Pregnancy Induces Sex and Region-Specific Alterations in the Offspring's Brain Redox Status.International journal of environmental research and public health · 2021Article
- Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer's Disease.Nutrients · 2020Review
- Amelioration of Scopolamine-Induced Amnesic, Anxiolytic and Antidepressant Effects ofMedicina (Kaunas, Lithuania) · 2020Article
- Phenolic Compounds ofMolecules (Basel, Switzerland) · 2019Article
- Synthesis of novel (-)-epicatechin derivatives as potential endothelial GPER agonists: Evaluation of biological effects.Bioorganic & medicinal chemistry letters · 2018Article
- Wine Flavonoids in Health and Disease Prevention.Molecules (Basel, Switzerland) · 2017Review
- Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins.Bioorganic & medicinal chemistry letters · 2013Article
- Neuroprotective effects of digested polyphenols from wild blackberry species.European journal of nutrition · 2013Article
- Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders.Biochemical and biophysical research communications · 2012Article
- Epicatechin used in the treatment of intestinal inflammatory disease: an analysis by experimental models.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties.Free radical biology & medicine · 2011Article
- Green tea extract for periodontal health.Journal of Indian Society of Periodontology · 2011Article
- Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation.American journal of physiology. Heart and circulatory physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is considerable current interest in the cytoprotective effects of natural antioxidants against oxidative stress. In particular, epicatechin, a major member of the flavanol family of polyphenols with powerful antioxidant properties in vitro, has been investigated to determine its ability to attenuate oxidative-stress-induced cell damage and to understand the mechanism of its protective action. We have induced oxidative stress in cultured human fibroblasts using hydrogen peroxide and examined the cellular responses in the form of mitochondrial function, cell-membrane damage, annexin-V binding and caspase-3 activation. Since one of the major metabolites of epicatechin in vivo is 3'-O-methyl epicatechin, we have compared its protective effects with that of epicatechin. The results provide the first evidence that 3'-O-methyl epicatechin inhibits cell death induced by hydrogen peroxide and that the mechanism involves suppression of caspase-3 activity as a marker for apoptosis. Furthermore, the protection elicited by 3'-O-methyl epicatechin is not significantly different from that of epicatechin, suggesting that hydrogen-donating antioxidant activity is not the primary mechanism of protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.