ArticleLeukemia2001
Screening for herpesvirus genomes in common acute lymphoblastic leukemia.
Article in Leukemia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A systematic review and meta-analysis of the association between childhood infections and the risk of childhood acute lymphoblastic leukaemia.British journal of cancer · 2018Pooled it
- Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence.Virology journal · 2022Article
- Association of population mixing and acute lymphocytic leukemia in children and young adults.Cancer epidemiology · 2020Article
- Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing.Haematologica · 2017Article
- In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia.Blood · 2017Article
- EBV, HCMV, HHV6, and HHV7 screening in bone marrow samples from children with acute lymphoblastic leukemia.BioMed research international · 2014Article
- History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia.Epigenetics · 2011Article
- Mannose-binding lectin genotypes and susceptibility to epstein-barr virus infection in infancy.Clinical and vaccine immunology : CVI · 2010Article
- Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601.Leukemia · 2009Article
- Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls.British journal of cancer · 2008Article
- Real-Time PCR: Revolutionizing Detection and Expression Analysis of Genes.Current genomics · 2007Article
- Infectious etiologies of childhood leukemia: plausibility and challenges to proof.Environmental health perspectives · 2007Review
- Article
- Real-time Fluorescent PCR Techniques to Study Microbial-Host Interactions.Methods in microbiology · 2004Review
- Qualitative and quantitative analysis of human herpesviruses in chronic and acute B cell lymphocytic leukemia and in multiple myeloma.Leukemia · 2003Article
- Antibody status to HHV-6 in children with leukaemia.Leukemia · 2002Article
- Real-time PCR in virology.Nucleic acids research · 2002Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is epidemiological evidence that infection may play a role in the etiology of childhood leukemia in particular common B cell precursor acute lymphoblastic leukemia. A panel of 20 leukemic samples (panel 1) was examined for the presence of four lymphotropic herpesviruses using conventional molecular techniques. A second independent panel of 27 leukemic samples (panel 2), along with 28 control peripheral blood samples from children with other forms of cancer, was tested for the presence of the same four viruses using sensitive real-time quantitative PCR. While herpesvirus genomes were detected, they were present at very low levels; detection rates and levels were similar in the leukemic and control panels. In addition we surveyed 18 leukemic samples (five from panel 1, six from panel 2 and a further seven samples not previously analyzed) using a degenerate PCR assay capable of detecting the genomes of known herpesviruses plus putative new members of the family. No novel herpesvirus genomes were detected suggesting that a herpesvirus is unlikely to be etiologically involved as a transforming agent in common acute lymphoblastic leukemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.