ArticleNature2001
Integration of telomere sequences with the draft human genome sequence.
Article in Nature, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Review
- Comprehensive Analysis of Human Subtelomeres by Whole Genome Mapping.PLoS genetics · 2020Article
- Hidden genomic evolution in a morphospecies-The landscape of rapidly evolving genes in Tetrahymena.PLoS biology · 2019Article
- High-throughput single-molecule mapping links subtelomeric variants and long-range haplotypes with specific telomeres.Nucleic acids research · 2017Article
- Family-based association study of DRD4 gene in methylphenidate-responded Attention Deficit/Hyperactivity Disorder.PloS one · 2017Article
- Subtelomere organization in the genome of the microsporidian Encephalitozoon cuniculi: patterns of repeated sequences and physicochemical signatures.BMC genomics · 2016Article
- Unique Combination of 22q11 and 14qter Microdeletion Syndromes Detected Using Oligonucleotide Array-CGH.Molecular syndromology · 2012Article
- Isolation and sequence analysis of the wheat B genome subtelomeric DNA.BMC genomics · 2009Article
- Recent acceleration of human adaptive evolution.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- BAC clones generated from sheared DNA.Genomics · 2007Article
- Human subtelomeric duplicon structure and organization.Genome biology · 2007Article
- Identification and fine mapping of AvrPi15, a novel avirulence gene of Magnaporthe grisea.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2006Article
- Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication.Nature · 2005Article
- Toward closing rice telomere gaps: mapping and sequence characterization of rice subtelomere regions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2005Article
- Human subtelomere structure and variation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Review
- Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes.Journal of virology · 2004Article
- The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.American journal of human genetics · 2004Article
- Mapping and initial analysis of human subtelomeric sequence assemblies.Genome research · 2004Article
- beta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation.Molecular psychiatry · 2003Article
- High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder.Molecular psychiatry · 2003Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres are the ends of linear eukaryotic chromosomes. To ensure that no large stretches of uncharacterized DNA remain between the ends of the human working draft sequence and the ends of each chromosome, we would need to connect the sequences of the telomeres to the working draft sequence. But telomeres have an unusual DNA sequence composition and organization that makes them particularly difficult to isolate and analyse. Here we use specialized linear yeast artificial chromosome clones, each carrying a large telomere-terminal fragment of human DNA, to integrate most human telomeres with the working draft sequence. Subtelomeric sequence structure appears to vary widely, mainly as a result of large differences in subtelomeric repeat sequence abundance and organization at individual telomeres. Many subtelomeric regions appear to be gene-rich, matching both known and unknown expressed genes. This indicates that human subtelomeric regions are not simply buffers of nonfunctional 'junk DNA' next to the molecular telomere, but are instead functional parts of the expressed genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.