ArticleRNA (New York, N.Y.)2001
Programmed +1 frameshifting stimulated by complementarity between a downstream mRNA sequence and an error-correcting region of rRNA.
Article in RNA (New York, N.Y.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- Control of gene expression by translational recoding.Advances in protein chemistry and structural biology · 2012Review
- Evolutionary comparison of ribosomal operon antitermination function.Journal of bacteriology · 2008Article
- A new kinetic model reveals the synergistic effect of E-, P- and A-sites on +1 ribosomal frameshifting.Nucleic acids research · 2008Article
- Saturation mutagenesis of a +1 programmed frameshift-inducing mRNA sequence derived from a yeast retrotransposon.RNA (New York, N.Y.) · 2007Article
- Expression of recombinant protein encoded by LOC387715 in Escherichia coli.Protein expression and purification · 2007Article
- An mRNA sequence derived from the yeast EST3 gene stimulates programmed +1 translational frameshifting.RNA (New York, N.Y.) · 2007Article
- Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.Nucleic acids research · 2007Review
- An mRNA sequence derived from a programmed frameshifting signal decreases codon discrimination during translation initiation.RNA (New York, N.Y.) · 2006Article
- Identification of Hepta- and Octo-Uridine stretches as sole signals for programmed +1 and -1 ribosomal frameshifting during translation of SARS-CoV ORF 3a variants.Nucleic acids research · 2006Article
- Translational accuracy during exponential, postdiauxic, and stationary growth phases in Saccharomyces cerevisiae.Eukaryotic cell · 2004Article
- P-site tRNA is a crucial initiator of ribosomal frameshifting.RNA (New York, N.Y.) · 2004Review
- Maintenance of the correct open reading frame by the ribosome.EMBO reports · 2003Article
- Predominance of six different hexanucleotide recoding signals 3' of read-through stop codons.Nucleic acids research · 2002Article
- Ribosome structure: revisiting the connection between translational accuracy and unconventional decoding.Trends in biochemical sciences · 2002Article
- Ribosomal pausing at a frameshifter RNA pseudoknot is sensitive to reading phase but shows little correlation with frameshift efficiency.Molecular and cellular biology · 2001Article
- Impact of the six nucleotides downstream of the stop codon on translation termination.EMBO reports · 2001Article
- Mechanisms and implications of programmed translational frameshifting.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Like most retroviruses and retrotransposons, the retrotransposon Ty3 expresses its pol gene analog (POL3) as a translational fusion to the upstream gag analog (GAG3). The Gag3-Pol3 fusion occurs by frameshifting during translation of the mRNA that encodes the two separate but overlapping ORFs. We showed previously that the shift occurs by out-of-frame binding of a normal aminoacyl-tRNA in the ribosomal A site caused by an aberrant codonoanticodon interaction in the P site. This event is unlike all previously described programmed translational frameshifts because it does not require tRNA slippage between cognate or near-cognate codons in the mRNA. A sequence of 15 nt distal to the frameshift site stimulates frameshifting 7.5-fold. Here we show that the Ty3 stimulator acts as an unstructured region to stimulate frameshifting. Its function depends on strict spacing from the site of frameshifting. Finally, the stimulator increases frameshifting dependent on sense codon-induced pausing, but has no effect on frameshifting dependent on pauses induced by nonsense codons. Complementarity between the stimulator and a portion of the accuracy center of the ribosome, Helix 18, implies that the stimulator may directly disrupt error correction by the ribosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.