ArticleAmerican journal of human genetics2001
Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 7 of them syntheses that pooled it.
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Who cites it
65 citing papers in PubMed, 7 syntheses or guidelines pooled it, 228 citations in OpenAlex.
- Association of rs4552569 and rs17095830 single-nucleotide polymorphisms with susceptibility to ankylosing spondylitis in east Asian population: a meta-analysis.Journal of genetics · 2018Pooled it
- Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: A Meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2017Pooled it
- Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Pooled it
- The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD).Annals of the rheumatic diseases · 2010Pooled it
- Meta-analysis of genome-wide linkage studies across autoimmune diseases.European journal of human genetics : EJHG · 2009Pooled it
- Novel non-HLA-susceptible regions determined by meta-analysis of four genomewide scans for ankylosing spondylitis.Journal of genetics · 2008Pooled it
- Ankylosing spondylitis susceptibility loci defined by genome-search meta-analysis.Journal of human genetics · 2005Pooled it
- Activating killer immunoglobulin-like receptors genes are associated with increased susceptibility to ankylosing spondylitis.Clinical and experimental immunology · 2015Trial
- The causal association between Celiac disease and Ankylosing spondylitis: a two-sample Mendelian randomization analysis.BMC rheumatology · 2026Article
- A Model of Type II Collagen-Induced Spondylitis and Arthritis in F1 Hybrid Male Mice.Bulletin of experimental biology and medicine · 2023Article
- Genome-wide association study reveals ethnicity-specific SNPs associated with ankylosing spondylitis in the Taiwanese population.Journal of translational medicine · 2022Article
- Recurrence of axial spondyloarthritis among first-degree relatives in a prospective 35-year-follow-up family study.RMD open · 2022Article
- Perspectives on the Genetic Associations of Ankylosing Spondylitis.Frontiers in immunology · 2021Review
- What Have We Learned From Family-Based Studies About Spondyloarthritis?Frontiers in genetics · 2021Review
- Genetics and Functional Genomics of Spondyloarthritis.Frontiers in immunology · 2018Review
- Complex Segregation Analysis Provides Evidence for Autosomal Dominant Transmission in the Chinese Han Families with Ankylosing Spondylitis.BioMed research international · 2017Article
- Genetics of ankylosing spondylitis--insights into pathogenesis.Nature reviews. Rheumatology · 2016Review
- A Genome-Wide SNP Linkage Analysis Suggests a Susceptibility Locus on 6p21 for Ankylosing Spondylitis and Inflammatory Back Pain Trait.PloS one · 2016Article
- Anti-TNFα agents and methotrexate in spondyloarthritis related uveitis in a Chinese population.Clinical rheumatology · 2015Article
- Prevalence of ankylosing spondylitis in Poland and costs generated by AS patients in the public healthcare system.Rheumatology international · 2015Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ankylosing spondylitis (AS) is a common inflammatory arthritis predominantly affecting the axial skeleton. Susceptibility to the disease is thought to be oligogenic. To identify the genes involved, we have performed a genomewide scan in 185 families containing 255 affected sibling pairs. Two-point and multipoint nonparametric linkage analysis was performed. Regions were identified showing "suggestive" or stronger linkage with the disease on chromosomes 1p, 2q, 6p, 9q, 10q, 16q, and 19q. The MHC locus was identified as encoding the greatest component of susceptibility, with an overall LOD score of 15.6. The strongest non-MHC linkage lies on chromosome 16q (overall LOD score 4.7). These results strongly support the presence of non-MHC genetic-susceptibility factors in AS and point to their likely locations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.