ArticleBMC public health2001
A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology.
Article in BMC public health, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2021Pooled it
- Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2020Pooled it
- Dynamic consent: a possible solution to improve patient confidence and trust in how electronic patient records are used in medical research.JMIR medical informatics · 2015Article
- Lack of association between measles virus vaccine and autism with enteropathy: a case-control study.PloS one · 2008Article
- Rate of first recorded diagnosis of autism and other pervasive developmental disorders in United Kingdom general practice, 1988 to 2001.BMC medicine · 2004Article
- Validation of the diagnosis of autism in general practitioner records.BMC public health · 2004Article
- The general practice research database: role in pharmacovigilance.Drug safety · 2004Review
- Review
- Brief report: immune factors in autism: a critical review.Journal of autism and developmental disorders · 2002Review
- Measles, mumps, and rubella (MMR) vaccine and autism. Ecological studies cannot answer main question.BMJ (Clinical research ed.) · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association between mumps-measles-rubella (MMR) vaccination and the onset of symptoms typical of autism has recently been suggested. This has led to considerable concern about the safety of the vaccine.
methodsA matched case-control study using data derived form the United Kingdom General Practice Research Database. Children with a possible diagnosis of autism will be identified from their electronic health records. All diagnoses will be validated by a detailed review of hospital letters and by using information derived from a parental questionnaire. Ten controls per case will be selected from the database. Conditional logistic regression will be used to assess the association between MMR vaccination and autism. In addition case series analyses will be undertaken to estimate the relative incidence of onset of autism in defined time intervals after vaccination. The study is funded by the United Kingdom Medical Research Council. DISCUSSION: Electronic health databases offer tremendous opportunities for evaluating the adverse effects of vaccines. However there is much scope for bias and confounding. The rigorous validation of all diagnoses and the collection of additional information by parental questionnaire in this study are essential to minimise the possibility of misleading results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.