ArticleThe Journal of physiology2001
The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- The placental tryptophan pathway across gestation: implications for pregnancy outcomes.Human reproduction update · 2026Review
- Melatonin modulates the gene expression of WEE1 kinase and clock genes: a crosstalk between the molecular clocks of the placenta?Frontiers in endocrinology · 2025Article
- The Role of the Kynurenine Pathway in the (Patho) physiology of Maternal Pregnancy and Fetal Outcomes: A Systematic Review.International journal of tryptophan research : IJTR · 2022Review
- The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?International journal of environmental research and public health · 2021Review
- Targeting Indoleamine 2,3-Dioxygenase 1: Fighting CancersFrontiers in immunology · 2021Review
- Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO.Frontiers in immunology · 2021Review
- The end of the road for the tryptophan depletion concept in pregnancy and infection.Clinical science (London, England : 1979) · 2016Review
- Solution-Phase Crosstalk and Regulatory Interactions Between Multipotent Adult Progenitor Cells and Peripheral Blood Mononuclear Cells.Stem cells translational medicine · 2015Article
- Tryptophan metabolism, disposition and utilization in pregnancy.Bioscience reports · 2015Review
- The tryptophan utilization concept in pregnancy.Obstetrics & gynecology science · 2014Review
- Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors.Frontiers in immunology · 2014Review
- Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells.Molecules (Basel, Switzerland) · 2013Article
- The role of placental indoleamine 2,3-dioxygenase in human pregnancy.Obstetrics & gynecology science · 2013Review
- IDO induces expression of a novel tryptophan transporter in mouse and human tumor cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Expression of indoleamine 2,3-dioxygenase in acute myeloid leukemia and the effect of its inhibition on cultured leukemia blast cells.Medical oncology (Northwood, London, England) · 2011Article
- Article
- Infectious tolerance via the consumption of essential amino acids and mTOR signaling.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Quantification of tryptophan transport and metabolism in lung tumors using PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2009Article
- Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation.The Journal of physiology · 2001Article
- Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta.The Biochemical journal · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physiological importance of L-tryptophan transport for placental indoleamine 2,3-dioxygenase-mediated degradation of L-tryptophan has been studied using human placental chorionic villous explants. L-Tryptophan influx into villous explants is supported exclusively by transport system L and is substantially inhibited by the L-system-specific substrate 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) and also by 1-methyl-tryptophan which is also an inhibitor of indoleamine 2,3-dioxygenase. L-Tryptophan influx is enhanced 2.3-fold following in vitro culture of the villous explant. Interferon-gamma, which increases villous explant indoleamine 2,3-dioxygenase expression, has no effect on L-tryptophan influx. In explants both BCH and 1-methyl-tryptophan inhibit indoleamine 2,3-dioxygenase-mediated L-tryptophan degradation. This also applies when L-tryptophan degradation has been stimulated by interferon-gamma. These findings show transport of L-tryptophan into the trophoblast to be a rate-limiting step for indoleamine 2,3-dioxygenase-mediated L-tryptophan degradation and therefore for the normal physiology of mammalian pregnancy.
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