ArticleThe Journal of physiology2001
Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial.Journal of translational medicine · 2013Trial
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- Plural molecular and cellular mechanisms of pore domainbioRxiv : the preprint server for biology · 2024Article
- Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron.Journal of computational neuroscience · 2013Article
- Article
- New tricks for old dogs: KCNQ expression and role in smooth muscle.British journal of pharmacology · 2009Review
- Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea.Audiology & neuro-otology · 2009Article
- Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates.PLoS genetics · 2008Article
- PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.The pharmacogenomics journal · 2007Article
- KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons.The Journal of physiology · 2006Article
- KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier.The Journal of physiology · 2006Article
- A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Cholinergic suppression of KCNQ channel currents enhances excitability of striatal medium spiny neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Differences between the negatively activating potassium conductances of Mammalian cochlear and vestibular hair cells.Journal of the Association for Research in Otolaryngology : JARO · 2004Article
- Ionic permeation and conduction properties of neuronal KCNQ2/KCNQ3 potassium channels.Biophysical journal · 2004Article
- KCNQ2 is a nodal K+ channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Mechanisms underlying modulation of neuronal KCNQ2/KCNQ3 potassium channels by extracellular protons.The Journal of general physiology · 2003Article
- KCNQ/M currents in sensory neurons: significance for pain therapy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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Authors and funding
6 authors.
Funding
Abstract
The region of alternative splicing in the KCNQ2 potassium channel gene was determined by RNase protection analysis of KCNQ2 mRNA transcripts. Systematic analysis of KCNQ2 alternative splice variant expression in rat superior cervical ganglia revealed multiple variant isoforms. One class of KCNQ2 splice variants, those that contained exon 15a, was found to have significantly different kinetics to those of the other isoforms. These transcripts encoded channel subunits that, when co-expressed with the KCNQ3 subunit, activated and deactivated approximately 2.5 times more slowly than other isoforms. Deletion of exon 15a in these isoforms produced a reversion to the faster kinetics. Comparison of the kinetic properties of the cloned channel splice variants with those of the native M-current suggests that alternative splicing of the KCNQ2 gene may contribute to the variation in M-current kinetics seen in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.