ArticleJournal of clinical microbiology2001
Identification of enteropathogenic Escherichia coli in simian immunodeficiency virus-infected infant and adult rhesus macaques.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Pathologic characteristics of infectious diseases in macaque monkeys used in biomedical and toxicologic studies.Journal of toxicologic pathology · 2023Review
- Phylogenetic Groups, Pathotypes and Antimicrobial Resistance ofPathogens (Basel, Switzerland) · 2022Article
- Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques.Toxicologic pathology · 2022Review
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- Genomic diversity ofMicrobial genomics · 2020Article
- Animal Models of Type III Secretion System-Mediated Pathogenesis.Pathogens (Basel, Switzerland) · 2019Review
- Paromomycin sulfate is an effective treatment for balantidiasis in captive cynomolgus monkeys.Experimental animals · 2019Article
- Captive wildlife from India as carriers of Shiga toxin-producing, Enteropathogenic and Enterotoxigenic Escherichia coli.The Journal of veterinary medical science · 2019Article
- Identification of Atypical EnteropathogenicFrontiers in veterinary science · 2017Article
- Longitudinal Characterization of Escherichia coli in Healthy Captive Non-Human Primates.Frontiers in veterinary science · 2014Article
- Characterization of cytotoxic necrotizing factor 1-producing Escherichia coli strains from faeces of healthy macaques.Journal of medical microbiology · 2009Article
- Escherichia coli, an Intestinal Microorganism, as a Biosensor for Quantification of Amino Acid Bioavailability.Sensors (Basel, Switzerland) · 2009Article
- Macaque models of human infectious disease.ILAR journal · 2008Review
- Identification and characterization of the locus for diffuse adherence, which encodes a novel afimbrial adhesin found in atypical enteropathogenic Escherichia coli.Infection and immunity · 2005Article
- Interspecies transmission of Enterozytozoon bieneusi supported by observations in laboratory animals and phylogeny.Medical microbiology and immunology · 2005Article
- Attaching-effacing bacteria in animals.Journal of comparative pathology · 2005Review
- Defining T-cell-mediated immune responses in rotavirus-infected juvenile rhesus macaques.Journal of virology · 2004Article
- Typing of intimin (eae) genes in attaching and effacing Escherichia coli strains from monkeys.Journal of clinical microbiology · 2004Article
- Infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques.Infection and immunity · 2003Article
- Characterization of monkey enteropathogenic Escherichia coli (EPEC) and human typical and atypical EPEC serotype isolates from neotropical nonhuman primates.Journal of clinical microbiology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Enteropathogenic Escherichia coli (EPEC) was recognized as a common opportunistic pathogen of simian immunodeficiency virus-infected rhesus macaques (Macaca mulatta) with AIDS. Retrospective analysis revealed that 27 of 96 (28.1%) animals with AIDS had features of EPEC infection, and EPEC was the most frequent pathogen of the gastrointestinal tract identified morphologically. In 7.3% of animals dying with AIDS, EPEC represented the sole opportunistic agent of the gastrointestinal tract at death. In 20.8% of cases, it was seen in combination with one or more gastrointestinal pathogens, including Cryptosporidium parvum, Enterocytozoon bieneusi, Mycobacterium avium, Entamoeba histolytica, Balantidium coli, Strongyloides stercoralis, cytomegalovirus, and adenovirus. Clinically, infection was associated with persistent diarrhea and wasting and was more frequent in animals that died at under 1 year of age (P < 0.001, Fisher exact test). The organism was associated with the characteristic attaching and effacing lesion in colonic tissue sections and produced a focal adherence pattern on a HEp-2 assay but was negative for Shiga toxin production as assessed by PCR and a HeLa cell cytotoxicity assay. A 2.6-kb fragment encompassing the intimin gene was amplified and sequenced and revealed 99.2% identity to sequences obtained from human isolates (GenBank AF116899) corresponding to the epsilon intimin subtype. Further investigations with rhesus macaques may offer opportunities to study the impact of EPEC on AIDS pathogenesis and gastrointestinal dysfunction.
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