ArticleGenome research2001
A bacterial artificial chromosome library for sequencing the complete human genome.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed.
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- Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model.Nucleic acids research · 2024Article
- Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer.BMC cancer · 2023Article
- Microfluidic Continuous Flow DNA Fragmentation based on a Vibrating Sharp-tip.Microfluidics and nanofluidics · 2022Article
- The enhancement of DNA fragmentation in a bench top ultrasonic water bath with needle-induced air bubbles: Simulation and experimental investigation.Biomicrofluidics · 2022Article
- Genomic medicine on the frontier of precision medicine.Journal of diabetes and metabolic disorders · 2022Review
- Progress in Methods for Copy Number Variation Profiling.International journal of molecular sciences · 2022Review
- Progress, Challenges, and Surprises in Annotating the Human Genome.Annual review of genomics and human genetics · 2020Review
- Cellular and genomic approaches for exploring structural chromosomal rearrangements.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Review
- Complete sequencing of the SMN2 gene in SMA patients detects SMN gene deletion junctions and variants in SMN2 that modify the SMA phenotype.Human genetics · 2019Article
- Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association.Circulation · 2018Review
- Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia.American journal of human genetics · 2018Article
- Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation.Scientific reports · 2018Article
- A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes.PloS one · 2018Article
- Beyond editing to writing large genomes.Nature reviews. Genetics · 2017Article
- Cross platform analysis of transcriptomic data identifies ageing has distinct and opposite effects on tendon in males and females.Scientific reports · 2017Article
- pBACode: a random-barcode-based high-throughput approach for BAC paired-end sequencing and physical clone mapping.Nucleic acids research · 2017Article
- Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics.Scientific reports · 2017Article
56 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
A 30-fold redundant human bacterial artificial chromosome (BAC) library with a large average insert size (178 kb) has been constructed to provide the intermediate substrate for the international genome sequencing effort. The DNA was obtained from a single anonymous volunteer, whose identity was protected through a double-blind donor selection protocol. DNA fragments were generated by partial digestion with EcoRI (library segments 1--4: 24-fold) and MboI (segment 5: sixfold) and cloned into the pBACe3.6 and pTARBAC1 vectors, respectively. The quality of the library was assessed by extensive analysis of 169 clones for rearrangements and artifacts. Eighteen BACs (11%) revealed minor insert rearrangements, and none was chimeric. This BAC library, designated as "RPCI-11," has been used widely as the central resource for insert-end sequencing, clone fingerprinting, high-throughput sequence analysis and as a source of mapped clones for diagnostic and functional studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.