ArticleGenes & development2001
Activation of the Notch-regulated transcription factor CBF1/RBP-Jkappa through the 13SE1A oncoprotein.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation.Cell communication and signaling : CCS · 2024Review
- Developments in Genetics: Better Management of Ovarian Cancer Patients.International journal of molecular sciences · 2023Review
- Review
- The human papillomavirus E7 oncoprotein as a regulator of transcription.Virus research · 2017Review
- The Varied Roles of Notch in Cancer.Annual review of pathology · 2017Review
- The anatomical distribution of genetic associations.Nucleic acids research · 2015Article
- Searching ChIP-seq genomic islands for combinatorial regulatory codes in mouse embryonic stem cells.BMC genomics · 2011Article
- Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development.The EMBO journal · 2011Article
- RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA.Journal of virology · 2004Article
- Is there a role for Notch signalling in human breast cancer?Breast cancer research : BCR · 2003Review
- The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.Genes & development · 2002Article
- Identification of a novel activation domain in the Notch-responsive transcription factor CSL.Nucleic acids research · 2001Article
- The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signaling through the Notch pathway controls cell growth and differentiation in metazoans. Following binding of its ligands, the intracellular part of the cell surface Notch1 receptor (Notch1-IC) is released and translocates to the nucleus, where it alters the function of the DNA-binding transcription factor CBF1/RBP-Jkappa. As a result, CBF1/RBP-Jkappa is converted from a repressor to an activator of gene transcription. Similarly, the Epstein Barr viral oncoprotein EBNA2, which is required for B-cell immortalization, activates genes through CBF1. Moreover, the TAN-1 and int-3 oncogenes represent activated versions of Notch1 and Notch4, respectively. Here, we show that the adenoviral oncoprotein 13S E1A also binds to CBF1/RBP-Jkappa, displaces associated corepressor complexes, and activates CBF1/RBP-Jkappa-dependent gene expression. Our results suggest that the central role of the Notch-CBF1/RBP-Jkappa signaling pathway in cell fate decisions renders it susceptible to pathways of viral replication and oncogenic conversion.
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