ArticleThe EMBO journal2001
The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 99 citations in OpenAlex.
- Article
- The mitochondrial CuFrontiers in molecular biosciences · 2022Article
- Gawky modulates MTF-1-mediated transcription activation and metal discrimination.Nucleic acids research · 2021Article
- Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins.Antioxidants (Basel, Switzerland) · 2021Review
- The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Promoter activity of earthworm metallothionein in mouse embryonic fibroblasts.Molecular biology reports · 2019Article
- Unravelling the Role of Metallothionein on Development, Reproduction and Detoxification in the Wall Lizard Podarcis sicula.International journal of molecular sciences · 2017Review
- Proteomic High Affinity ZnInternational journal of molecular sciences · 2017Review
- Regulatory Plasticity of Earthworm wMT-2 Gene Expression.International journal of molecular sciences · 2017Article
- Metallothionein in Brain Disorders.Oxidative medicine and cellular longevity · 2017Review
- Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.Nucleic acids research · 2012Article
- The role of small ubiquitin-like modifier-interacting motif in the assembly and regulation of metal-responsive transcription factor 1.The Journal of biological chemistry · 2011Article
- Article
- Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1.Molecular and cellular biology · 2008Article
- Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila.BMC developmental biology · 2008Article
- The genetics of essential metal homeostasis during development.Genesis (New York, N.Y. : 2000) · 2008Review
- Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection.BMC genomics · 2008Article
- Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5).Biological chemistry · 2007Article
- USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.Molecular and cellular biology · 2007Article
- The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers.Molecular and cellular biology · 2006Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
During early development of the mouse embryo, expression of the metallothionein-I (MT-I) gene is heightened specifically in the endoderm cells of the visceral yolk sac. The mechanisms of regulation of this cell-specific pattern of expression of metallothionein-I are unknown. However, it has recently been shown that MTF-1, functioning as a metalloregulatory transcription factor, activates metallothionein genes in response to the essential metal zinc. In contrast with the metallothionein genes, MTF-1 is essential for development; null mutant embryos die due to liver degeneration. We report here that MTF-1 is absolutely essential for upregulation of MT-I gene expression in visceral endoderm cells and that optimal expression also involves interactions of the basic helix-loop-helix upstream stimulatory factor-1 (USF1) with an E-box1-containing sequence at -223 bp in the MT-I promoter. Expression of MT-I in visceral endoderm cells was dependent on maternal dietary zinc. Thus, the essential metal, zinc, apparently provides the signaling ligand that activates cell-specific MT-I expression in visceral endoderm cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.