ArticleApplied and environmental microbiology2001
Dual role of GdmH in producer immunity and secretion of the Staphylococcal lantibiotics gallidermin and epidermin.
Article in Applied and environmental microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- A Staphylococcus capitis strain with unusual bacteriocin production.Microbial biotechnology · 2023Article
- Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis.Antimicrobial agents and chemotherapy · 2020Article
- LanI-Mediated Lantibiotic Immunity in Bacillus subtilis: Functional Analysis.Applied and environmental microbiology · 2019Article
- Lantibiotic production is a burden for the producing staphylococci.Scientific reports · 2018Article
- Bifunctional gene cluster lnqBCDEF mediates bacteriocin production and immunity with differential genetic requirements.Applied and environmental microbiology · 2013Article
- Review
- Highly efficient Staphylococcus carnosus mutant selection system based on suicidal bacteriocin activation.Applied and environmental microbiology · 2012Article
- Identification of a genetic locus responsible for antimicrobial peptide resistance in Clostridium difficile.Infection and immunity · 2011Article
- Oxidation of lanthionines renders the lantibiotic nisin inactive.Applied and environmental microbiology · 2009Article
- The early response to acid shock in Lactobacillus reuteri involves the ClpL chaperone and a putative cell wall-altering esterase.Applied and environmental microbiology · 2007Article
- Circumventing the effect of product toxicity: development of a novel two-stage production process for the lantibiotic gallidermin.Applied and environmental microbiology · 2007Article
- Role of the single regulator MrsR1 and the two-component system MrsR2/K2 in the regulation of mersacidin production and immunity.Applied and environmental microbiology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biosynthetic gene clusters of the staphylococcal lantibiotics epidermin and gallidermin are distinguished by the presence of the unique genes epiH and gdmH, respectively. They encode accessory factors for the ATP-binding cassette transporters that mediate secretion of the antimicrobial peptides. Here, we show that gdmH also contributes to immunity to gallidermin but not to nisin. gdmH alone affected susceptibility to gallidermin only moderately, but it led to a multiplication of the immunity level mediated by the FEG immunity genes when cloned together with the gdmT gene, suggesting a synergistic activity of the H and FEG systems. gdmH-related genes were identified in the genomes of several bacteria, indicating an involvement in further cellular functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.