ArticleProceedings of the National Academy of Sciences of the United States of America2001
In vivo evidence for a cochlear amplifier in the hair-cell bundle of lizards.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 102 citations in OpenAlex.
- The mechanisms of frequency tuning in gecko auditory hair cells.Hearing research · 2025Review
- The continued importance of comparative auditory research to modern scientific discovery.Hearing research · 2023Review
- Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea.Hearing research · 2022Article
- Otoacoustic Emissions in Non-Mammals.Audiology research · 2022Review
- Atypical tuning and amplification mechanisms in gecko auditory hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Physiological Basis of Noise-Induced Hearing Loss in a Tympanal Ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Travelling waves and tonotopicity in the inner ear: a historical and comparative perspective.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Comparative Auditory Neuroscience: Understanding the Evolution and Function of Ears.Journal of the Association for Research in Otolaryngology : JARO · 2017Review
- Article
- Loss of the tectorial membrane protein CEACAM16 enhances spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The effects of air pressure on spontaneous otoacoustic emissions of lizards.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
- Article
- Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley type model of sensory hair cells.Journal of mathematical neuroscience · 2011Article
- Prestin and the cholinergic receptor of hair cells: positively-selected proteins in mammals.Hearing research · 2011Review
- Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?Hearing research · 2011Article
- The remarkable cochlear amplifier.Hearing research · 2010Article
- Interactions between hair cells shape spontaneous otoacoustic emissions in a model of the tokay gecko's cochlea.PloS one · 2010Article
- Effectiveness of hair bundle motility as the cochlear amplifier.Biophysical journal · 2009Article
- Enhancement of sensitivity gain and frequency tuning by coupling of active hair bundles.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate sensory hair cells achieve high sensitivity and frequency selectivity by adding self-generated mechanical energy to low-level signals. This allows them to detect signals that are smaller than thermal molecular motion and to achieve significant resonance amplitudes and frequency selectivity despite the viscosity of the surrounding fluid. In nonmammals, a great deal of in vitro evidence indicates that the active process responsible for this amplification is intimately associated with the hair cells' transduction channels in the stereovillar bundle. Here, we provide in vivo evidence of hair-cell bundle involvement in active processes. Electrical stimulation of the inner ear of a lizard at frequencies typical for this hearing organ induced low-level otoacoustic emissions that could be modulated by low-frequency sound. The unique modulation pattern permitted the tracing of the active process involved to the stereovillar bundles of the sensory hair cells. This supports the notion that, in nonmammals, the cochlear amplifier in the hair cells is driven by a bundle motor system.
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