ArticleProceedings of the National Academy of Sciences of the United States of America2001
Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 73 citations in OpenAlex.
- The CDK8 kinase module: A novel player in the transcription of translation initiation and ribosomal genes.Molecular biology of the cell · 2025Article
- Ssn6 Interacts with Polar Tube Protein 2 and Transcriptional Repressor for RNA Polymerase II: Insight into Its Involvement in the Biological Process of MicrosporidiumJournal of fungi (Basel, Switzerland) · 2023Article
- Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1.Current genetics · 2023Article
- Interdependent recruitment of CYC8/TUP1 and the transcriptional activator XYR1 at target promoters is required for induced cellulase gene expression in Trichoderma reesei.PLoS genetics · 2021Article
- TheG3 (Bethesda, Md.) · 2017Article
- Ssn6-Tup1 global transcriptional co-repressor: Role of the N-terminal glutamine-rich region of Ssn6.PloS one · 2017Article
- Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture.Journal of the American Chemical Society · 2016Article
- Crystal structure of the N-terminal domain of the yeast general corepressor Tup1p and its functional implications.The Journal of biological chemistry · 2012Article
- Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast.The EMBO journal · 2012Article
- Activator control of nucleosome occupancy in activation and repression of transcription.PLoS biology · 2008Article
- Sir2 silences gene transcription by targeting the transition between RNA polymerase II initiation and elongation.Molecular and cellular biology · 2008Article
- Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26.Molecular biology of the cell · 2008Article
- The transcription corepressor LEUNIG interacts with the histone deacetylase HDA19 and mediator components MED14 (SWP) and CDK8 (HEN3) to repress transcription.Molecular and cellular biology · 2007Article
- Individual subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes.Molecular and cellular biology · 2007Article
- Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling.Eukaryotic cell · 2006Article
- Genome-wide analysis of the functions of a conserved surface on the corepressor Tup1.Molecular biology of the cell · 2005Article
- Combinatorial repression of the hypoxic genes of Saccharomyces cerevisiae by DNA binding proteins Rox1 and Mot3.Eukaryotic cell · 2005Article
- Transcriptional activating regions target attached substrates to a cyclin-dependent kinase.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Promoter-dependent roles for the Srb10 cyclin-dependent kinase and the Hda1 deacetylase in Tup1-mediated repression in Saccharomyces cerevisiae.Molecular biology of the cell · 2004Article
- Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yeast transcriptional repressor Tup1, tethered to DNA, represses to strikingly different degrees transcription elicited by members of two classes of activators. Repression in both cases is virtually eliminated by mutation of either member of the cyclin-kinase pair Srb10/11. In contrast, telomeric chromatin affects both classes of activators equally, and in neither case is that repression affected by mutation of Srb10/11. In vitro, Tup1 interacts with RNA polymerase II holoenzyme bearing Srb10 as well as with the separated Srb10. These and other findings indicate that at least one aspect of Tup1's action involves interaction with the RNA polymerase II holoenzyme.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.