ArticleThe Plant cell2001
Transgene-induced silencing identifies sequences involved in the establishment of paramutation of the maize p1 gene.
Article in The Plant cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 91 citations in OpenAlex.
- Enhancers in Plant Development, Adaptation and Evolution.Plant & cell physiology · 2025Review
- Paramutation at the maize pl1 locus is associated with RdDM activity at distal tandem repeats.PLoS genetics · 2024Article
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- Article
- Epimutations and mutations, nurturing phenotypic diversity.Genetica · 2022Review
- Mendelian and non-Mendelian genetics in model plants.The Plant cell · 2022Article
- Tissue culture-induced DNA methylation in crop plants: a review.Molecular biology reports · 2021Review
- DNA demethylase ROS1 prevents inheritable DREB1A/CBF3 repression by transgene-induced promoter methylation in the Arabidopsis ice1-1 mutant.Plant molecular biology · 2020Article
- Locus-specific paramutation in Zea mays is maintained by a PICKLE-like chromodomain helicase DNA-binding 3 protein controlling development and male gametophyte function.PLoS genetics · 2020Article
- Genetic control of non-genetic inheritance in mammals: state-of-the-art and perspectives.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Review
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- Genome-wide mapping of transcriptional enhancer candidates using DNA and chromatin features in maize.Genome biology · 2017Article
- Article
- Paramutation and related phenomena in diverse species.Nature reviews. Genetics · 2017Review
- P1 Epigenetic Regulation in Leaves of High Altitude Maize Landraces: Effect of UV-B Radiation.Frontiers in plant science · 2016Article
- Trans-Homolog Interactions Facilitating Paramutation in Maize.Plant physiology · 2015Review
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- Diverse gene-silencing mechanisms with distinct requirements for RNA polymerase subunits in Zea mays.Genetics · 2014Article
- Epigenetics: Beyond Chromatin Modifications and Complex Genetic Regulation.Plant physiology · 2014Review
- Covering your bases: inheritance of DNA methylation in plant genomes.Molecular plant · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A transgene carrying a distal enhancer element of the maize P1-rr promoter caused silencing of an endogenous P1-rr allele in the progeny of transgenic maize plants. Expression of both the transgene and the endogenous P1-rr allele was reduced in the affected plants. The silenced phenotype was observed in the progeny of seven of eight crosses involving three independent transgenic events tested (average frequency of 19%). This phenotype was associated with an induced epigenetic state of the P1-rr allele, termed P1-rr', which is characterized by increased methylation of the P1-rr flanking regions and decreased levels of P1-rr transcript. The P1-rr' epiallele is highly heritable in the absence of the inducing P1.2b::GUS transgene, and it can impose an equivalent state on a naive P1-rr allele in subsequent crosses (paramutation). In contrast, parallel experiments with two other P::GUS transgenes that contained the same basal P1-rr promoter fragment but different upstream sequences revealed no detectable silencing effect. Thus, transgenes carrying a specific enhancer fragment of the P1-rr gene promoter can trigger a paramutant state (P1-rr') of the endogenous P1-rr gene that is maintained in the absence of the inducing transgene. We discuss the potential role of the P1-rr distal enhancer element in the establishment and propagation of a paramutation system in maize.
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