ArticleThe EMBO journal2001
Reconstitution of Epstein-Barr virus-based plasmid partitioning in budding yeast.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Review
- A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus.Disease models & mechanisms · 2014Article
- Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface.Journal of virology · 2014Article
- Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance.RNA (New York, N.Y.) · 2012Article
- Proteomic profiling of EBNA1-host protein interactions in latent and lytic Epstein-Barr virus infections.Journal of virology · 2012Article
- Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis.Journal of virology · 2012Article
- The Epstein-Barr Virus EBNA1 Protein.Scientifica · 2012Review
- Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.Molecular and cellular biology · 2011Article
- Replication and transcription of human papillomavirus type 58 genome in Saccharomyces cerevisiae.Virology journal · 2010Article
- Mitotic chromosome interactions of Epstein-Barr nuclear antigen 1 (EBNA1) and human EBNA1-binding protein 2 (EBP2).Journal of cell science · 2009Article
- Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment.Journal of virology · 2009Article
- Targeting mitotic chromosomes: a conserved mechanism to ensure viral genome persistence.Proceedings. Biological sciences · 2009Review
- The selfish yeast plasmid uses the nuclear motor Kip1p but not Cin8p for its localization and equal segregation.The Journal of cell biology · 2009Article
- The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4.Journal of virology · 2008Article
- Analysis of cis-elements that facilitate extrachromosomal persistence of human papillomavirus genomes.Virology · 2008Article
- Review
- Herpesvirus saimiri episomal persistence is maintained via interaction between open reading frame 73 and the cellular chromosome-associated protein MeCP2.Journal of virology · 2007Article
- Regulation of the EBNA1 Epstein-Barr virus protein by serine phosphorylation and arginine methylation.Journal of virology · 2006Article
- Episomal maintenance of plasmids with hybrid origins in mouse cells.Journal of virology · 2005Article
- EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases.Molecular and cellular biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The EBNA1 protein of Epstein-Barr virus (EBV) mediates the partitioning of EBV episomes and EBV-based plasmids during cell division by a mechanism that appears to involve binding to the cellular EBP2 protein on human chromosomes. We have investigated the ability of EBNA1 and the EBV segregation element (FR) to mediate plasmid partitioning in Saccharomyces cerevisiae. EBNA1 expression alone did not enable the stable segregation of FR-containing plasmids in yeast, but segregation was rescued by human EBP2. The reconstituted segregation system required EBNA1, human EBP2 and the FR element, and functionally replaced a CEN element. An EBP2 binding mutant of EBNA1 and an EBNA1 binding mutant of EBP2 each failed to support FR-plasmid partitioning, indicating that an EBNA1-EBP2 interaction is required. The results provide direct evidence of the role of hEBP2 in EBNA1-mediated segregation and demonstrate that heterologous segregation systems can be reconstituted in yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.