ArticleBritish journal of pharmacology2001
The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- The endocannabinoid system and breathing.Frontiers in neuroscience · 2023Review
- Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS.BioMed research international · 2015Article
- Antitussive drugs--past, present, and future.Pharmacological reviews · 2014Review
- Sensory nerves and airway irritability.Handbook of experimental pharmacology · 2009Review
- Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.Handbook of experimental pharmacology · 2009Review
- Review
- The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.European journal of pharmacology · 2007Article
- TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs.Cough (London, England) · 2006Article
- Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung.British journal of pharmacology · 2005Article
- Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1-/- mice.The Journal of physiology · 2004Article
- Anandamide and vanilloid TRPV1 receptors.British journal of pharmacology · 2003Review
- Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide.British journal of pharmacology · 2002Article
- Anandamide induces cough in conscious guinea-pigs through VR1 receptors.British journal of pharmacology · 2002Article
- Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons.British journal of pharmacology · 2002Article
- Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve.British journal of pharmacology · 2002Article
- Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors.The Journal of physiology · 2002Article
- Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat.British journal of pharmacology · 2001Article
- A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.British journal of pharmacology · 2001Article
- Pharmacology of airway afferent nerve activity.Respiratory research · 2001Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endogenous cannabinoid agonist, anandamide produced a modest contractile response in guinea-pig isolated bronchus compared with the vanilloid receptor agonist capsaicin. The contractile response to both anandamide and capsaicin was inhibited by the vanilloid receptor antagonist, capsazepine. Furthermore, the NK(2)-selective antagonist, SR48968 but not the NK(1)-selective antagonist, SR140333 inhibited contractile responses to anandamide. The contractile response to anandamide was abolished in tissues desensitized by capsaicin. However, anandamide failed to cross-desensitize the contractile response to capsaicin. The contractile response to anandamide was not significantly altered in the presence of the CB(1) receptor antagonist, SR141716A, nor the amidase inhibitor, phenylmethylsulphonyl fluoride (PMSF) but was significantly increased in the presence of the neutral endopeptidase inhibitor, thiorphan. The cannabinoid agonist, CP55,940 failed to significantly attenuate the excitatory non-adrenergic non-cholinergic (eNANC) response in guinea-pig airways. In contrast, the ORL(1) receptor agonist, nociceptin, significantly inhibited this response. The results demonstrate that anandamide induces a modest contractile response in guinea-pig isolated bronchus that is dependent upon the activation of vanilloid receptors on airway sensory nerves. However, cannabinoid receptors do not appear to play a role in this regard, nor in regulating the release of neuropeptides from airway sensory nerves under physiological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.