ReviewAnnals of surgery2001
Molecular biology of Barrett's adenocarcinoma.
Review in Annals of surgery, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- p53 and Ki-67 combined with periodic acid-Schiff staining for the diagnosis of early stage esophageal squamous cell carcinoma lesions in biopsy specimens.Esophagus : official journal of the Japan Esophageal Society · 2025Article
- Cancer Prevention in Low-Resource Countries: An Overview of the Opportunity.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2020Article
- Pathology of esophageal cancer and Barrett's esophagus.Annals of cardiothoracic surgery · 2017Review
- Expression of COX2 and p53 in Rat Esophageal Cancer Induced by Reflux of Duodenal Contents.ISRN gastroenterology · 2012Article
- Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus.Gastroenterology research and practice · 2012Article
- Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma.International journal of clinical and experimental pathology · 2012Review
- Risk factors for neoplastic progression in Barrett's esophagus.World journal of gastroenterology · 2011Review
- GI GEMs: genetically engineered mouse models of gastrointestinal disease.Gastroenterology · 2011Review
- Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.Gastroenterology · 2010Article
- Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis.Nature reviews. Cancer · 2010Review
- Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma.International journal of cancer · 2009Article
- Evaluation of fatty acid synthase expression in oesophageal mucosa of patients with oesophagitis, Barrett's oesophagus and adenocarcinoma.Journal of cancer research and clinical oncology · 2009Article
- Factors associated with carcinoma of the oesophagus at Mulago Hospital, Uganda.African health sciences · 2008Article
- Absence of Na+/sugar cotransport activity in Barrett's metaplasia.World journal of gastroenterology · 2008Article
- Patients' perception of diagnostic tests in the preoperative assessment of esophageal cancer.Patient preference and adherence · 2008Article
- COX-2 mRNA expression is significantly increased in acid-exposed compared to nonexposed squamous epithelium in gastroesophageal reflux disease.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- An evaluation of prognostic factors and tumor staging of resected carcinoma of the esophagus.Annals of surgery · 2007Article
- Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha.The Biochemical journal · 2007Article
- Outcome of surgical treatment for early adenocarcinoma of the esophagus or gastro-esophageal junction.Virchows Archiv : an international journal of pathology · 2005Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review the current knowledge on the genetic alterations involved in the development and progression of Barrett's esophagus-associated neoplastic lesions. SUMMARY BACKGROUND DATA: Barrett's esophagus (BE) is a premalignant condition in which the normal squamous epithelium of the esophagus is replaced by metaplastic columnar epithelium. BE predisposes patients to the development of esophageal adenocarcinoma. Endoscopic surveillance can detect esophageal adenocarcinomas when they are early and curable, but most of the adenocarcinomas are detected at an advanced stage. Despite advances in multimodal therapy, the prognosis for invasive esophageal adenocarcinoma is poor. A better understanding of the molecular evolution of the Barrett's metaplasia to dysplasia to adenocarcinoma sequence may allow improved diagnosis, therapy, and prognosis.
methodsThe authors reviewed data from the published literature to address what is known about the molecular changes thought to be important in the pathogenesis of BE-associated neoplastic lesions.
resultsThe progression of Barrett's metaplasia to adenocarcinoma is associated with several changes in gene structure, gene expression, and protein structure. Some of the molecular alterations already showed promise as markers for early cancer detection or prognostication. Among these, alterations in the p53 and p16 genes and cell cycle abnormalities or aneuploidy appear to be the most important and well-characterized molecular changes. However, the exact sequence of events is not known, and probably multiple molecular pathways interact and are involved in the progression of BE to adenocarcinoma.
conclusionsFurther research into the molecular biology of BE-associated adenocarcinoma will enhance our understanding of the genetic events critical for the initiation and progression of Barrett's adenocarcinoma, leading to more effective surveillance and treatment.
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