ArticleScience (New York, N.Y.)2001
Taste receptor cells that discriminate between bitter stimuli.
Article in Science (New York, N.Y.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B.Animal models and experimental medicine · 2024Article
- Contribution of TRPC3-mediated CaPflugers Archiv : European journal of physiology · 2023Article
- Article
- Advances in Optical Tools to Study Taste Sensation.Molecules and cells · 2022Review
- Encoding Taste: From Receptors to Perception.Handbook of experimental pharmacology · 2022Article
- The tongue map and the spatial modulation of taste perception.Current research in food science · 2022Review
- "Tripartite Synapses" in Taste Buds: A Role for Type I Glial-like Taste Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts.Frontiers in immunology · 2021Article
- Chemospecific deficits in taste sensitivity following bilateral or right hemispheric gustatory cortex lesions in rats.The Journal of comparative neurology · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- G Protein-Coupled Receptors in Taste Physiology and Pharmacology.Frontiers in pharmacology · 2020Review
- Rats are unable to discriminate quinine from diverse bitter stimuli.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Gingival solitary chemosensory cells are immune sentinels for periodontitis.Nature communications · 2019Article
- The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Recognizing Taste: Coding Patterns Along the Neural Axis in Mammals.Chemical senses · 2019Review
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae.Neuroscience · 2018Article
- Innate and acquired tolerance to bitter stimuli in mice.PloS one · 2018Article
- Taste buds: cells, signals and synapses.Nature reviews. Neuroscience · 2017Review
- The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.Frontiers in physiology · 2017Article
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Abstract
Recent studies showing that single taste bud cells express multiple bitter taste receptors have reignited a long-standing controversy over whether single gustatory receptor cells respond selectively or broadly to tastants. We examined calcium responses of rat taste receptor cells in situ to a panel of bitter compounds to determine whether individual cells distinguish between bitter stimuli. Most bitter-responsive taste cells were activated by only one out of five compounds tested. In taste cells that responded to multiple stimuli, there were no significant associations between any two stimuli. Bitter sensation does not appear to occur through the activation of a homogeneous population of broadly tuned bitter-sensitive taste cells. Instead, different bitter stimuli may activate different subpopulations of bitter-sensitive taste cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.