ArticleNucleic acids research2001
Regulation of c-maf gene expression by Pax6 in cultured cells.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4Nature communications · 2023Article
- The role and regulation of Maf proteins in cancer.Biomarker research · 2023Review
- Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.The Journal of biological chemistry · 2016Article
- Stimulation of mouse Cyp1b1 during adipogenesis: characterization of promoter activation by the transcription factor Pax6.Archives of biochemistry and biophysics · 2013Article
- 3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes.PloS one · 2012Article
- The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.The Journal of biological chemistry · 2011Article
- Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function.The Journal of biological chemistry · 2010Article
- Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis.Molecular biology of the cell · 2010Article
- Effects of elevated Pax6 expression and genetic background on mouse eye development.Investigative ophthalmology & visual science · 2009Article
- Pax6 is essential for lens fiber cell differentiation.Development (Cambridge, England) · 2009Article
- Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Genetic and epigenetic mechanisms of gene regulation during lens development.Progress in retinal and eye research · 2007Review
- Pax6 is misexpressed in Sox1 null lens fiber cells.Gene expression patterns : GEP · 2007Article
- Sequential and combinatorial roles of maf family genes define proper lens development.Molecular vision · 2007Article
- Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin.The EMBO journal · 2006Article
- Crystallization and preliminary X-ray analysis of the Pax6 paired domain bound to the Pax6 gene enhancer.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005Article
- Tissue-specific regulation of the mouse alphaA-crystallin gene in lens via recruitment of Pax6 and c-Maf to its promoter.Journal of molecular biology · 2005Article
- Ocular coloboma: a reassessment in the age of molecular neuroscience.Journal of medical genetics · 2004Review
- Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis.The Biochemical journal · 2004Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
c-Maf is a bZip transcription factor expressed in developmental and cellular differentiation processes. Recently, a c-maf knockout mouse model, showing abnormal lens development, has been reported. In order to study the regulation mechanisms of c-maf gene expression during the differentiation process we have cloned and functionally characterized the rat c-maf (maf-2) gene. The rat c-maf gene is an intronless gene, covering a length of 3.5 kb. Transient transfection analysis of the 5'-flanking region of the c-maf gene using luciferase as the reporter gene shows that Pax6, a master transcription factor for lens development, strongly activates the c-maf promoter construct. Endogenous c-maf is also activated by the Pax6 expression vector. Electrophoresis mobility shift assay and DNase I footprinting analysis show that at least three Pax6-binding sites are located in the 5'-flanking and 5'-non-coding regions of the rat c-maf gene. The c-maf gene was also markedly activated by its own product, c-Maf, through the MARE (Maf recognition element), suggesting that a positive autoregulatory mechanism controls this gene. In situ hybridization histochemical detection of Pax6 and c-Maf in the E14 lens showed that both mRNAs are expressed in the lens equator where lens epithelial cells are differentiating to lens fiber cells. These results suggest that a Pax6/c-Maf transcription factor cascade is working in lens development.
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