ArticleJournal of virology2001
Simian immunodeficiency virus (SIV) infection of a rhesus macaque induces SIV-specific CD8(+) T cells with a defect in effector function that is reversible on extended interleukin-2 incubation.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Trial
- Article
- Insights Into Persistent HIV-1 Infection and Functional Cure: Novel Capabilities and Strategies.Frontiers in microbiology · 2022Review
- Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication.Frontiers in immunology · 2018Article
- Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection.Journal of virology · 2017Article
- Host genetics play a critical role in controlling CD8 T cell function and lethal immunopathology during chronic viral infection.PLoS pathogens · 2017Article
- Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/KFrontiers in immunology · 2017Article
- Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors.Journal of leukocyte biology · 2016Article
- Animal models for viral infection and cell exhaustion.Current opinion in HIV and AIDS · 2014Review
- T-cell memory differentiation: insights from transcriptional signatures and epigenetics.Immunology · 2013Review
- Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice.The Journal of clinical investigation · 2010Article
- Article
- Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection.Journal of virology · 2009Article
- Review
- Emerging concepts in the immunopathogenesis of AIDS.Annual review of medicine · 2009Review
- Article
- Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection.Springer seminars in immunopathology · 2006Review
- HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.Virology · 2006Article
- The fate of effector CD8 T cells in vivo is controlled by the duration of antigen stimulation.Immunology · 2006Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A vigorous expansion of antigen-specific CD8(+) T cells lacking apparent effector function was observed in a rhesus macaque acutely infected with the simian immunodeficiency virus (SIV) strain SIVmac239. Antigen-specific CD8(+) T cells were identified using antigenic-peptide class I major histocompatibility complex tetramers. As many as 8.3% of CD8(+) cells recognized the Mamu-A*01-associated SIV epitope Gag(181-189) (CTPYDINQM); however, these cells demonstrated no effector function when presented with peptide-incubated targets, as measured by intracellular cytokine staining for gamma interferon (IFN-gamma), interleukin-2 (IL-2) production, or direct cellular lysis. Similar results were observed with three other SIV peptide antigens. Nonresponsiveness did not correlate with apoptosis of the CD8(+) cells, nor were cells from this macaque impaired in their ability to present peptide antigens. Associated with the nonresponsive state was a lack of IL-2 production and decreased IL-2 receptor expression. Exogenous IL-2 treatment for 1 week in the absence of antigenic stimulation restored antigen-specific responses and the quantitative correlation between tetramer recognition and antigen-responsive IFN-gamma secretion. This case report suggests a regulatory mechanism that may impede the effector function of antigen-specific T cells during acute infection with SIV or human immunodeficiency virus in some cases. This mechanism may participate in the failure of the immune system to limit infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.