ArticleJournal of virology2001
Antiviral response in cells containing Stat1 with heterologous transactivation domains.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The Aqueous Leaf Extract of the Medicinal HerbViruses · 2023Article
- Targeting High-Risk Neuroblastoma Patient-Derived Xenografts with Oncolytic Virotherapy.Cancers · 2022Article
- Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation.Frontiers in immunology · 2018Review
- The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment.Frontiers in immunology · 2018Article
- Intraindividual dynamics of transcriptome and genome-wide stability of DNA methylation.Scientific reports · 2016Article
- Article
- Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains.The EMBO journal · 2009Article
- Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.Molecular and cellular biology · 2004Article
- The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.The EMBO journal · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The STATs (signal transducers and activators of transcription), latent cytoplasmic transcription factors, are activated by binding of extracellular polypeptides to cell surface receptors. Dimerization, accumulation in the nucleus, and transcriptional inductions of specific genes then occur. The COOH terminus of the STATs acts as a transcriptional activation domain (TAD). Stat1, one of seven mammalian STAT genes, forms a homodimer after activation by gamma interferon and induces transcription of a number of genes. These induced genes in turn produce the antiviral state. In the present experiments we used a Stat1-deficient cell line complemented with Stat1 or various fusion constructs in which the wild-type Stat1 TAD was replaced by other TADs to test the possibility that a specific activating domain was necessary for the induction of the antiviral response. We found that a wide variety of TADs with different activation potential appended to the Stat1 COOH terminus could substitute for the wild-type protein in inducing the antiviral state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.