ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Neural network partitioning by NO and cGMP.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.Proceedings of the National Academy of Sciences of the United States of America · 2006Trial
- Multiple intrinsic membrane properties are modulated in a switch from single- to dual-network activity.Journal of neurophysiology · 2022Article
- A review of the actions of Nitric Oxide in development and neuronal function in major invertebrate model systems.AIMS neuroscience · 2019Review
- Diffusible gas transmitter signaling in the copepod crustacean Calanus finmarchicus: identification of the biosynthetic enzymes of nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) using a de novo assembled transcriptome.General and comparative endocrinology · 2014Article
- Article
- Beyond the wiring diagram: signalling through complex neuromodulator networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- The nitric oxide/cGMP pathway tunes the thermosensitivity of swimming motor patterns in Xenopus laevis tadpoles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Modification of the effects of glutamate by nitric oxide (NO) in a pattern-generating network.Neuroscience and behavioral physiology · 2008Article
- Nitric oxide in the crustacean brain: regulation of neurogenesis and morphogenesis in the developing olfactory pathway.Developmental dynamics : an official publication of the American Association of Anatomists · 2007Article
- Characterization of NO/cGMP-mediated responses in identified motoneurons.Cellular and molecular neurobiology · 2007Article
- Arthropod 5-HT2 receptors: a neurohormonal receptor in decapod crustaceans that displays agonist independent activity resulting from an evolutionary alteration to the DRY motif.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Nitric oxide inhibits the rate and strength of cardiac contractions in the lobster Homarus americanus by acting on the cardiac ganglion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Actions of a histaminergic/peptidergic projection neuron on rhythmic motor patterns in the stomatogastric nervous system of the crab Cancer borealis.The Journal of comparative neurology · 2004Article
- Regulation of neuronal proliferation and differentiation by nitric oxide.Molecular neurobiology · 2003Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The stomatogastric ganglion (STG) of the crab Cancer productus contains approximately 30 neurons arrayed into two different networks (gastric mill and pyloric), each of which produces a distinct motor pattern in vitro. Here we show that the functional division of the STG into these two networks requires intact NO-cGMP signaling. Multiple nitric oxide synthase (NOS)-like proteins are expressed in the stomatogastric nervous system, and NO appears to be released as an orthograde transmitter from descending inputs to the STG. The receptor of NO, a soluble guanylate cyclase (sGC), is expressed in a subset of neurons in both motor networks. When NO diffusion or sGC activation are blocked within the ganglion, the two networks combine into a single conjoint circuit. The gastric mill motor rhythm breaks down, and several gastric neurons pattern switch and begin firing in pyloric time. The functional reorganization of the STG is both rapid and reversible, and the gastric mill motor rhythm is restored when the ganglion is returned to normal saline. Finally, pharmacological manipulations of the NO-cGMP pathway are ineffective when descending modulatory inputs to the STG are blocked. This suggests that the NO-cGMP pathway may interact with other biochemical cascades to partition rhythmic motor output from the ganglion.
Indexed as
Identifiers
11222651PMC6762929W1535064698What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.