ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Regulation of mouse kappa opioid receptor gene expression by retinoids.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022Review
- Genome-wide Analysis of RARβ Transcriptional Targets in Mouse Striatum Links Retinoic Acid Signaling with Huntington's Disease and Other Neurodegenerative Disorders.Molecular neurobiology · 2017Article
- Targeting Retinoid Receptors to Treat Schizophrenia: Rationale and Progress to Date.CNS drugs · 2016Review
- Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Transcriptional and epigenetic regulation of opioid receptor genes: present and future.Annual review of pharmacology and toxicology · 2011Review
- Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia.Molecular pain · 2010Article
- Regulation of stress granule dynamics by Grb7 and FAK signalling pathway.The EMBO journal · 2008Article
- Article
- The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation.The EMBO journal · 2007Article
- Axonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root ganglia.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors.The Journal of biological chemistry · 2006Article
- Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Nutrigenomics: integrating genomic approaches into nutrition research.Molecular diagnosis & therapy · 2006Review
- Retinoic acid-induced chromatin remodeling of mouse kappa opioid receptor gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Post-transcriptional regulation of opioid receptors in the nervous system.Frontiers in bioscience : a journal and virtual library · 2004Review
- A novel signaling pathway of nitric oxide on transcriptional regulation of mouse kappa opioid receptor gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The effect of retinoids on the expression of kappa opioid receptor (KOR) gene was examined in normal and transgenic animals. KOR-lacZ transgene expression was specifically elevated in KOR-positive areas of the developing CNS by depleting vitamin A from animal diets. The endogenous KOR mRNA species, including all three isoforms, were also upregulated by depleting vitamin A in developing animals. Change in the expression of isoforms a and b is similar in prenatal stages but differs during postnatal development. Interestingly, upregulation of isoform c is most significant postnatally. The regulation of KOR gene by vitamin A was substantiated in a mouse embryonal carcinoma P19 culture system in which retinoic acid (RA), the most potent ingredient of vitamin A, was able to suppress the expression of all the three KOR isoforms and KOR protein. The RA-mediated suppression was blocked by an RA receptor antagonist and a histone deacetylase (HDAC) inhibitor. By using a reporter transfection assay in P19 cells, the potential genetic element responsible for RA-mediated suppression of KOR gene expression was located to intron 1 of the mouse KOR gene, which could also be blocked by HDAC inhibitor. Furthermore, suppression of KOR gene expression by RA in P19 cells appeared to be an indirect event and required protein synthesis. A role of RA in KOR gene regulation during developmental stages was discussed.
Indexed as
Identifiers
11222649PMC6762951W1505001285What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.