ArticleBiophysical journal2001
Axial disposition of myosin heads in isometrically contracting muscles.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Optogenetic induction of mechanical muscle stress identifies myosin regulatory ubiquitin ligase NHL-1 in C. elegans.Nature communications · 2024Article
- Anisotropic Elasticity of the Myosin Motor in Muscle.International journal of molecular sciences · 2022Article
- Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing.The Journal of general physiology · 2021Article
- Monitoring the myosin crossbridge cycle in contracting muscle: steps towards 'Muscle-the Movie'.Journal of muscle research and cell motility · 2019Review
- Myosin filament activation in the heart is tuned to the mechanical task.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Actomyosin interaction at low ATP concentrations.European biophysics journal : EBJ · 2017Article
- Head-head interactions of resting myosin crossbridges in intact frog skeletal muscles, revealed by synchrotron x-ray fiber diffraction.PloS one · 2012Article
- Geometrical conditions indispensable for muscle contraction.International journal of molecular sciences · 2011Article
- Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions.PloS one · 2010Article
- Actomyosin-ADP states, interhead cooperativity, and the force-velocity relation of skeletal muscle.Biophysical journal · 2010Article
- The mechanism of the resistance to stretch of isometrically contracting single muscle fibres.The Journal of physiology · 2010Article
- Direct modeling of X-ray diffraction pattern from contracting skeletal muscle.Biophysical journal · 2008Article
- Structural changes in the myosin filament and cross-bridges during active force development in single intact frog muscle fibres: stiffness and X-ray diffraction measurements.The Journal of physiology · 2006Article
- RECENT IMPROVEMENTS IN SMALL ANGLE X-RAY DIFFRACTION FOR THE STUDY OF MUSCLE PHYSIOLOGY.Reports on progress in physics. Physical Society (Great Britain) · 2006Article
- Cross-bridge number, position, and angle in target zones of cryofixed isometrically active insect flight muscle.Biophysical journal · 2004Article
- The conformation of myosin head domains in rigor muscle determined by X-ray interference.Biophysical journal · 2003Article
- Direct modeling of x-ray diffraction pattern from skeletal muscle in rigor.Biophysical journal · 2002Article
- Changes in myosin S1 orientation and force induced by a temperature increase.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A model of cross-bridge attachment to actin in the A*M*ATP state based on x-ray diffraction from permeabilized rabbit psoas muscle.Biophysical journal · 2002Article
- Structural characterization of weakly attached cross-bridges in the A*M*ATP state in permeabilized rabbit psoas muscle.Biophysical journal · 2002Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meridional x-ray diffraction diagrams, recorded with high angular resolution, from muscles contracting at the plateau of isometric tension show that the myosin diffraction orders are clusters of peaks. These clusters are due to pronounced interference effects between the myosin diffracting units on either side of the M-line. A theoretical analysis based on the polarity of the myosin (and actin) filaments shows that it is possible to extract phase information from which the axial disposition of the myosin heads can be determined. The results show that each head in a crown pair has a distinct structural disposition. It appears that only one of the heads in the pair stereospecifically interacts with the thin filament at any one time.
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