ArticleBiophysical journal2001
Lipid membrane expansion and micelle formation by polymer-grafted lipids: scaling with polymer length studied by spin-label electron spin resonance.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Effects of grafted polymers on the lipid membrane fluidity.Biophysical journal · 2024Article
- Insights into Membrane Curvature Sensing and Membrane Remodeling by Intrinsically Disordered Proteins and Protein Regions.The Journal of membrane biology · 2022Review
- Structure Versus Stochasticity-The Role of Molecular Crowding and Intrinsic Disorder in Membrane Fission.Journal of molecular biology · 2018Review
- Membrane fission by protein crowding.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Engineering chemically modified viruses for prostate cancer cell recognition.Molecular bioSystems · 2015Article
- Intrinsically disordered proteins drive membrane curvature.Nature communications · 2015Article
- Microfluidic synthesis of PEG- and folate-conjugated liposomes for one-step formation of targeted stealth nanocarriers.Pharmaceutical research · 2013Article
- Investigations on the melting and bending modulus of polymer grafted bilayers using dissipative particle dynamics.Biomicrofluidics · 2010Article
- In vitro and in vivo effects of polyethylene glycol (PEG)-modified lipid in DOTAP/cholesterol-mediated gene transfection.International journal of nanomedicine · 2010Article
- Kinetics of stearic acid transfer between human serum albumin and sterically stabilized liposomes.European biophysics journal : EBJ · 2010Article
- Spontaneous transfer of stearic acids between human serum albumin and PEG:2000-grafted DPPC membranes.European biophysics journal : EBJ · 2010Article
- Effect of the lipid chain melting transition on the stability of DSPE-PEG(2000) micelles.Langmuir : the ACS journal of surfaces and colloids · 2009Article
- Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery.Journal of controlled release : official journal of the Controlled Release Society · 2009Article
- Thin liquid films and monolayers of DMPC mixed with PEG and phospholipid linked PEG.European biophysics journal : EBJ · 2006Article
- Influence of the long-chain/short-chain amphiphile ratio on lateral diffusion of PEG-lipid in magnetically aligned lipid bilayers as measured via pulsed-field-gradient NMR.Biophysical journal · 2005Article
- Scaling and mean-field theories applied to polymer brushes.Biophysical journal · 2004Article
- Liposomes, disks, and spherical micelles: aggregate structure in mixtures of gel phase phosphatidylcholines and poly(ethylene glycol)-phospholipids.Biophysical journal · 2003Article
- The effect of chain length on protein solubilization in polymer-based vesicles (polymersomes).Biophysical journal · 2003Article
- Osmotic properties of poly(ethylene glycols): quantitative features of brush and bulk scaling laws.Biophysical journal · 2003Article
- Elastic constants of polymer-grafted lipid membranes.Biophysical journal · 2001Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spin-label electron spin resonance (ESR) spectroscopy and auxiliary optical density measurements are used to study lipid dispersions of N-poly(ethylene glycol)-dipalmitoyl phosphatidylethanolamine (PEG:5000-DPPE) mixed with dipalmitoyl phosphatidylcholine (DPPC). PEG:5000-DPPE bears a large hydrophilic polymer headgroup (with approximately 114 oxyethylene monomers) and is commonly used for steric stabilization of liposomes used in drug delivery. Comparison is made with results from mixtures of DPPC with polymer lipids bearing shorter headgroups (approximately 45 and 8 oxyethylene monomers). ESR spectra of phosphatidylcholine spin-labeled on the 5-C atom position of the sn-2 chain are shown to reflect the area expansion of the lipid membranes by the lateral pressure exerted in the polymer brush, in a way that is consistent with theory. The lipid chain packing density at the onset of micelle formation is the same for all three PEG-lipids, although the mole fraction at which this occurs differs greatly. The mole fraction at onset scales inversely with the size of the polymer headgroup, where the experimental exponent of 0.7 is close to theoretical predictions (viz. 0.55-0.6). The mole fraction of PEG-lipid at completion of micelle formation is more weakly dependent on polymer size, which conforms with theoretical predictions. At high mole fractions of PEG:5000-DPPE the dependence of lipid packing density on mole fraction is multiphasic, which differs qualitatively from the monotonic decrease in packing density found with the shorter polymer lipids. Lipid spin-label ESR is an experimental tool that complements theoretical analysis using polymer models combined with the lipid equation of state.
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